Presurgical evaluation and surgical outcome of temporal lobe epilepsy

Vicenta Salanova, Omkar Markand, Robert Worth, Bhuwan Garg, Hema Patel, Jorge Asconape, Hee Myung Park, Gary Hutchins, Robert Smith, Biagio Azzarelli

Research output: Contribution to journalArticle

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Abstract

The authors analyzed 22 patients younger than 18 years of age with temporal lobe epilepsy (TLE) treated surgically. Patients underwent a comprehensive pre-surgical evaluation, including video-electroencephalogram. Fifty-five percent had a history of febrile seizures. Eighty-two percent had auraes and most exhibited oroalimentary and gestural automatisms. Contralateral dystonic posturing was present in 36% and postictal dysphasia in 54% of patients with left-sided resections. Cranial magnetic resonance imaging (MRI) was abnormal in 59% of patients. MRI revealed changes consistent with mesial temporal sclerosis in 8 (47%) of 17 patients without lesions. Fluorodeoxyglucose-positron emission tomography (PET) scans revealed ipsilateral temporal hypometabolism (PET-TH) in 12 (85.7%) of 14 patients. The intracarotid amobarbital procedure revealed impaired memory of the epileptogenic side in 59% of patients. Seventeen patients underwent en-bloc resections and five lesionectomies and resection of the epileptogenic area. There was no surgical morbidity or mortality. Forty-three percent had hippocampal sclerosis, 28.5% gliosis, 14% low-grade tumors, 9.5% cavernous angiomas, and 5% had no pathologic findings. Follow-up (6 months to 12 years) was available for 21 patients; 76% became seizure free, 19% had rare seizures, and 5% had a worthwhile improvement. TLE can be safely treated surgically in younger patients with excellent results. The clinical manifestations were similar to adult patients. PET-TH was present even at a younger age, suggesting that the focal functional deficits appear early in patients with medically refractory TLE, which may help in the early identification of these patients.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalPediatric Neurology
Volume20
Issue number3
DOIs
StatePublished - Mar 1999

Fingerprint

Temporal Lobe Epilepsy
Operative Time
Positron-Emission Tomography
Sclerosis
Seizures
Magnetic Resonance Imaging
Automatism
Amobarbital
Febrile Seizures
Cavernous Hemangioma
Gliosis
Aphasia
Electroencephalography

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Presurgical evaluation and surgical outcome of temporal lobe epilepsy. / Salanova, Vicenta; Markand, Omkar; Worth, Robert; Garg, Bhuwan; Patel, Hema; Asconape, Jorge; Park, Hee Myung; Hutchins, Gary; Smith, Robert; Azzarelli, Biagio.

In: Pediatric Neurology, Vol. 20, No. 3, 03.1999, p. 179-184.

Research output: Contribution to journalArticle

Salanova, V, Markand, O, Worth, R, Garg, B, Patel, H, Asconape, J, Park, HM, Hutchins, G, Smith, R & Azzarelli, B 1999, 'Presurgical evaluation and surgical outcome of temporal lobe epilepsy', Pediatric Neurology, vol. 20, no. 3, pp. 179-184. https://doi.org/10.1016/S0887-8994(98)00128-3
Salanova, Vicenta ; Markand, Omkar ; Worth, Robert ; Garg, Bhuwan ; Patel, Hema ; Asconape, Jorge ; Park, Hee Myung ; Hutchins, Gary ; Smith, Robert ; Azzarelli, Biagio. / Presurgical evaluation and surgical outcome of temporal lobe epilepsy. In: Pediatric Neurology. 1999 ; Vol. 20, No. 3. pp. 179-184.
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