Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study

for the, Dominantly Inherited Alzheimer Network (DIAN)

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Introduction Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials. Methods Serial T1-weighted magnetic resonance imaging scans of 94 participants (28 noncarriers, 66 carriers) from the Dominantly Inherited Alzheimer Network were used to measure brain, ventricular, and hippocampal atrophy rates. For each structure, nonlinear mixed-effects models estimated the change-points when atrophy rates deviate from normal and the rates of change before and after this point. Results Atrophy increased after the change-point, which occurred 1–1.5 years (assuming a single step change in atrophy rate) or 3–8 years (assuming gradual acceleration of atrophy) before expected symptom onset. At expected symptom onset, estimated atrophy rates were at least 3.6 times than those before the change-point. Discussion Atrophy rates are pathologically increased up to seven years before “expected onset”. During this period, atrophy rates may be useful for inclusion and tracking of disease progression.

Original languageEnglish (US)
Pages (from-to)43-53
Number of pages11
JournalAlzheimer's and Dementia
Volume14
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Alzheimer's disease
  • Atrophy
  • Autosomal dominant
  • Boundary Shift Integral
  • Change-point
  • Dementia
  • Longitudinal
  • MRI
  • Neuroimaging
  • Nonlinear modeling

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study'. Together they form a unique fingerprint.

  • Cite this