Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia

Meijing Wang, Ben M. Tsai, Paul R. Crisostomo, Daniel R. Meldrum

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Cardiogenic shock from myocardial ischemia is the leading cause of death of both men and women. Although adult progenitor cells have emerged as a potential therapy for heart disease, reports indicate that transplanted adult progenitor cells may not differentiate into heart muscle. We hypothesized that pretreatment with adult progenitor cells may protect myocardium from acute ischemic damage. Treatment immediately before an ischemic event removes the possibility that differentiation to heart muscle may account for the observed effects. In the present study, we determined that adult progenitor cells from three different sources (human bone marrow, rat bone marrow, and human adipose tissue) immediately protect native myocardium against ischemia and decrease myocardial proinflammatory and proapoptotic signaling. Postischemic recovery of adult progenitor cell-pretreated hearts was significantly better than that of control hearts. This was correlated with a 50% decrease in proinflammatory cytokine production. The use of a differentiated cell control had no such effect. Therefore, adult progenitor cell pretreatment improved postischemic myocardial function, decreased myocardial production of inflammatory mediators, and limited proapoptotic signaling. These results represent the first demonstration that pretreatment with progenitor cells is myocardial protective. These findings may not only have mechanistic implications regarding the benefit of progenitor cells but may also have clinical therapeutic implications before planned ischemic events.

Original languageEnglish
Pages (from-to)454-459
Number of pages6
JournalShock
Volume25
Issue number5
DOIs
StatePublished - May 2006

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Stem Cells
Ischemia
Myocardium
Myocardial Ischemia
Bone Marrow
Cardiogenic Shock
Adipose Tissue
Cause of Death
Heart Diseases
Therapeutics
Cytokines

Keywords

  • Cell-based therapy
  • Inflammatory signaling
  • Myocardial ischemia
  • Stem cells

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia. / Wang, Meijing; Tsai, Ben M.; Crisostomo, Paul R.; Meldrum, Daniel R.

In: Shock, Vol. 25, No. 5, 05.2006, p. 454-459.

Research output: Contribution to journalArticle

Wang, Meijing ; Tsai, Ben M. ; Crisostomo, Paul R. ; Meldrum, Daniel R. / Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia. In: Shock. 2006 ; Vol. 25, No. 5. pp. 454-459.
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