Prevalence and course of strabismus through age 6 years in participants of the Early Treatment for Retinopathy of Prematurity randomized trial

Deborah K. Vanderveen, Don L. Bremer, Rae R. Fellows, Robert J. Hardy, Daniel E. Neely, Earl A. Palmer, David L. Rogers, Betty Tung, William V. Good

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Abstract

Purpose: To present strabismus data for children who participated in the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial. Methods: The prevalence of strabismus, categorized as present or absent, was tabulated for all children with history of high-risk prethreshold retinopathy of prematurity (ROP) who participated in the ETROP randomized trial and were examined at 9 months to 6 years of age. Relationships among strabismus and demographic measures, eye characteristics, and neurodevelopmental factors were analyzed. Results: Among the 342 children evaluated at 6 years, the prevalence of strabismus was 42.2%. Even with favorable acuity scores in both eyes, the prevalence of strabismus was 25.4%, and with favorable structural outcomes in both eyes the prevalence of strabismus was 34.2%. Of children categorized as visually impaired as the result of either ocular or cerebral causes, 80% were strabismic at the 6-year examination. Of 103 study participants who were strabismic at 9 months, 77 (74.8%) remained so at 6 years. Most strabismus was constant at both the 9-month (62.7%) and the 6-year examination (72.3%). After multiple logistic regression analysis, risk factors for strabismus were abnormal fixation behavior in one or both eyes (P < 0.001), history of amblyopia (P < 0.003), unfavorable structural outcome in one or both eyes (P = 0.025), and history of anisometropia (P = 0.04). Strabismus surgery was performed for 53 children. By 6 years, the cumulative prevalence of strabismus was 59.4%. Conclusions: Most children with a history of high-risk prethreshold ROP develop strabismus at some time during the first 6 years of life.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalJournal of AAPOS
Volume15
Issue number6
DOIs
StatePublished - Dec 1 2011

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

Vanderveen, D. K., Bremer, D. L., Fellows, R. R., Hardy, R. J., Neely, D. E., Palmer, E. A., Rogers, D. L., Tung, B., & Good, W. V. (2011). Prevalence and course of strabismus through age 6 years in participants of the Early Treatment for Retinopathy of Prematurity randomized trial. Journal of AAPOS, 15(6), 536-540. https://doi.org/10.1016/j.jaapos.2011.07.017