Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke

Walter N. Kernan, Catherine M. Viscoli, Silvia E. Inzucchi, Lawrence M. Brass, Dawn M. Bravata, Gerald I. Shulman, James C. McVeety

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102 Scopus citations

Abstract

Background: Despite current preventive therapies, patients with transient ischemic attack (TIA) and ischemic stroke remain at high risk for recurrent brain disease and cardiovascular events. In an effort to develop new therapies, abnormal glucose tolerance has recently been proposed as an interventional target. Among persons not otherwise known to be diabetic, impaired glucose tolerance (IGT) and diabetic glucose tolerance (DGT) are each associated with an increased risk for incident vascular disease, vascular disease mortality, and allcause mortality. We conducted this study to determine if IGT and DGT are sufficiently common among patients with TIA and ischemic stroke to warrant therapeutic trials of antihyperglycemic agents. Motheds: Men and women older than 45 years were recruited from 3 hospitals in south central Connecticut. Eligibility criteria included a recent TIA or nondisabling ischemic stroke, no history of physician-diagnosed diabetes mellitus, and a fasting plasma glucose level less than 126 mg/dL (<7.0 mmol/L). After an overnight fast, subjects were admitted to a clinical research center for a standard 75-g oral glucose tolerance test. Impaired glucose tolerance was defined by a 2-hour plasma glucose value of 140 to 199 mg/dL (7.8-11.0 mmol/L) and DGT by a value of 200 mg/dL or greater (≥11.1 mmol/L). Results: Between June 2000 and August 2003, we enrolled 98 eligible patients. The average time from TIA or stroke to measurement of glucose tolerance was 105 days (range, 24-180 days) and the median age was 71 years. Twenty-seven subjects (28%) had IGT and 24 (24%) had diabetes. In a forward stepwise logistic regression model, only a fasting plasma glucose level of 110 mg/dL or greater (≥6.1 mmol/L) and lower waist circumference were associated with an increased risk for IGT or DGT. Conclusions: Impaired glucose tolerance and DGT are present in most persons with a recent TIA or ischemic stroke who have no history of diabetes and a fasting plasma glucose level less than 126 mg/dL (<7.0 mmol/L). Our findings bring new urgency to the initiation of research to examine the effectiveness of antihyperglycemic therapies among patients with cerebrovascular disease and abnormal glucose tolerance.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalArchives of Internal Medicine
Volume165
Issue number2
DOIs
StatePublished - Jan 24 2005
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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    Kernan, W. N., Viscoli, C. M., Inzucchi, S. E., Brass, L. M., Bravata, D. M., Shulman, G. I., & McVeety, J. C. (2005). Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke. Archives of Internal Medicine, 165(2), 227-233. https://doi.org/10.1001/archinte.165.2.227