Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke

Walter N. Kernan, Catherine M. Viscoli, Silvia E. Inzucchi, Lawrence M. Brass, Dawn Bravata, Gerald I. Shulman, James C. McVeety

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Background: Despite current preventive therapies, patients with transient ischemic attack (TIA) and ischemic stroke remain at high risk for recurrent brain disease and cardiovascular events. In an effort to develop new therapies, abnormal glucose tolerance has recently been proposed as an interventional target. Among persons not otherwise known to be diabetic, impaired glucose tolerance (IGT) and diabetic glucose tolerance (DGT) are each associated with an increased risk for incident vascular disease, vascular disease mortality, and allcause mortality. We conducted this study to determine if IGT and DGT are sufficiently common among patients with TIA and ischemic stroke to warrant therapeutic trials of antihyperglycemic agents. Motheds: Men and women older than 45 years were recruited from 3 hospitals in south central Connecticut. Eligibility criteria included a recent TIA or nondisabling ischemic stroke, no history of physician-diagnosed diabetes mellitus, and a fasting plasma glucose level less than 126 mg/dL (

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalArchives of Internal Medicine
Volume165
Issue number2
DOIs
StatePublished - Jan 24 2005
Externally publishedYes

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Transient Ischemic Attack
Stroke
Glucose
Glucose Intolerance
Vascular Diseases
Mortality
Brain Diseases
Hypoglycemic Agents
Fasting
Diabetes Mellitus
Therapeutics
Physicians

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Kernan, W. N., Viscoli, C. M., Inzucchi, S. E., Brass, L. M., Bravata, D., Shulman, G. I., & McVeety, J. C. (2005). Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke. Archives of Internal Medicine, 165(2), 227-233. https://doi.org/10.1001/archinte.165.2.227

Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke. / Kernan, Walter N.; Viscoli, Catherine M.; Inzucchi, Silvia E.; Brass, Lawrence M.; Bravata, Dawn; Shulman, Gerald I.; McVeety, James C.

In: Archives of Internal Medicine, Vol. 165, No. 2, 24.01.2005, p. 227-233.

Research output: Contribution to journalArticle

Kernan, Walter N. ; Viscoli, Catherine M. ; Inzucchi, Silvia E. ; Brass, Lawrence M. ; Bravata, Dawn ; Shulman, Gerald I. ; McVeety, James C. / Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke. In: Archives of Internal Medicine. 2005 ; Vol. 165, No. 2. pp. 227-233.
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