Prevalence of pain and association with quality of life, depression and glycaemic control in patients with diabetes

Matthew Bair, E. J. Brizendine, R. T. Ackermann, C. Shen, Kurt Kroenke, David Marrero

Research output: Contribution to journalArticle

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Abstract

Aims To determine the prevalence of pain and its association with glycaemic control, mental health and physical functioning in patients with diabetes. Methods Cross-sectional data from a multi-site, prospective cohort study of 11 689 participants with diabetes. We analysed the associations of pain severity and interference with glycated haemoglobin (HbA<inf>1c</inf>) measurements and Medical Outcomes Study SF - Mental and Physical Component Summary-12 (MCS-12 and PCS-12) scores. Results Of participants, 57.8% reported moderate to extreme pain and, compared with those without pain, were somewhat older (60.8 vs. 59.9 years, P < 0.001), more obese (body mass index of 32.1 vs. 29.8 kg/m <sup>2</sup>, P < 0.001), more likely to report being depressed or anxious (41.3 vs. 16.2%, P < 0.001) and more likely to report fair or poor health (48.5 vs. 23.1%, P < 0.001). Bivariate comparisons demonstrated that patients with extreme pain had higher HbA<inf>1c</inf> than those without pain (8.3 vs. 8.0%, P = 0.001). In multivariable analyses, pain was not associated with HbA<inf>1c</inf> (P = 0.304) but was strongly associated with worse MCS-12 (P < 0.001), PCS-12 (P < 0.001) and depression (P < 0.001). Depression was 1.3 (95% CI: 1.12, 1.96) times more likely in patients with moderate pain and 2.0 (95% CI: 1.56, 2.46) times more likely in patients with extreme pain. Conclusions Moderate to extreme pain was present in 57.8% of diabetic patients. Pain was strongly associated with poorer mental health and physical functioning, but not worse glycaemic control. Recognizing the high prevalence of pain and its strong association with poorer health-related quality of life may be important to improve the comprehensive management of diabetes.

Original languageEnglish
Pages (from-to)578-584
Number of pages7
JournalDiabetic Medicine
Volume27
Issue number5
DOIs
StatePublished - 2010

Fingerprint

Quality of Life
Depression
Pain
Mental Health
Glycosylated Hemoglobin A
Cohort Studies
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • Depression
  • Diabetes mellitus
  • Glycaemic control
  • Pain
  • Quality of life

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Prevalence of pain and association with quality of life, depression and glycaemic control in patients with diabetes. / Bair, Matthew; Brizendine, E. J.; Ackermann, R. T.; Shen, C.; Kroenke, Kurt; Marrero, David.

In: Diabetic Medicine, Vol. 27, No. 5, 2010, p. 578-584.

Research output: Contribution to journalArticle

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abstract = "Aims To determine the prevalence of pain and its association with glycaemic control, mental health and physical functioning in patients with diabetes. Methods Cross-sectional data from a multi-site, prospective cohort study of 11 689 participants with diabetes. We analysed the associations of pain severity and interference with glycated haemoglobin (HbA1c) measurements and Medical Outcomes Study SF - Mental and Physical Component Summary-12 (MCS-12 and PCS-12) scores. Results Of participants, 57.8{\%} reported moderate to extreme pain and, compared with those without pain, were somewhat older (60.8 vs. 59.9 years, P < 0.001), more obese (body mass index of 32.1 vs. 29.8 kg/m 2, P < 0.001), more likely to report being depressed or anxious (41.3 vs. 16.2{\%}, P < 0.001) and more likely to report fair or poor health (48.5 vs. 23.1{\%}, P < 0.001). Bivariate comparisons demonstrated that patients with extreme pain had higher HbA1c than those without pain (8.3 vs. 8.0{\%}, P = 0.001). In multivariable analyses, pain was not associated with HbA1c (P = 0.304) but was strongly associated with worse MCS-12 (P < 0.001), PCS-12 (P < 0.001) and depression (P < 0.001). Depression was 1.3 (95{\%} CI: 1.12, 1.96) times more likely in patients with moderate pain and 2.0 (95{\%} CI: 1.56, 2.46) times more likely in patients with extreme pain. Conclusions Moderate to extreme pain was present in 57.8{\%} of diabetic patients. Pain was strongly associated with poorer mental health and physical functioning, but not worse glycaemic control. Recognizing the high prevalence of pain and its strong association with poorer health-related quality of life may be important to improve the comprehensive management of diabetes.",
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AU - Bair, Matthew

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AU - Shen, C.

AU - Kroenke, Kurt

AU - Marrero, David

PY - 2010

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N2 - Aims To determine the prevalence of pain and its association with glycaemic control, mental health and physical functioning in patients with diabetes. Methods Cross-sectional data from a multi-site, prospective cohort study of 11 689 participants with diabetes. We analysed the associations of pain severity and interference with glycated haemoglobin (HbA1c) measurements and Medical Outcomes Study SF - Mental and Physical Component Summary-12 (MCS-12 and PCS-12) scores. Results Of participants, 57.8% reported moderate to extreme pain and, compared with those without pain, were somewhat older (60.8 vs. 59.9 years, P < 0.001), more obese (body mass index of 32.1 vs. 29.8 kg/m 2, P < 0.001), more likely to report being depressed or anxious (41.3 vs. 16.2%, P < 0.001) and more likely to report fair or poor health (48.5 vs. 23.1%, P < 0.001). Bivariate comparisons demonstrated that patients with extreme pain had higher HbA1c than those without pain (8.3 vs. 8.0%, P = 0.001). In multivariable analyses, pain was not associated with HbA1c (P = 0.304) but was strongly associated with worse MCS-12 (P < 0.001), PCS-12 (P < 0.001) and depression (P < 0.001). Depression was 1.3 (95% CI: 1.12, 1.96) times more likely in patients with moderate pain and 2.0 (95% CI: 1.56, 2.46) times more likely in patients with extreme pain. Conclusions Moderate to extreme pain was present in 57.8% of diabetic patients. Pain was strongly associated with poorer mental health and physical functioning, but not worse glycaemic control. Recognizing the high prevalence of pain and its strong association with poorer health-related quality of life may be important to improve the comprehensive management of diabetes.

AB - Aims To determine the prevalence of pain and its association with glycaemic control, mental health and physical functioning in patients with diabetes. Methods Cross-sectional data from a multi-site, prospective cohort study of 11 689 participants with diabetes. We analysed the associations of pain severity and interference with glycated haemoglobin (HbA1c) measurements and Medical Outcomes Study SF - Mental and Physical Component Summary-12 (MCS-12 and PCS-12) scores. Results Of participants, 57.8% reported moderate to extreme pain and, compared with those without pain, were somewhat older (60.8 vs. 59.9 years, P < 0.001), more obese (body mass index of 32.1 vs. 29.8 kg/m 2, P < 0.001), more likely to report being depressed or anxious (41.3 vs. 16.2%, P < 0.001) and more likely to report fair or poor health (48.5 vs. 23.1%, P < 0.001). Bivariate comparisons demonstrated that patients with extreme pain had higher HbA1c than those without pain (8.3 vs. 8.0%, P = 0.001). In multivariable analyses, pain was not associated with HbA1c (P = 0.304) but was strongly associated with worse MCS-12 (P < 0.001), PCS-12 (P < 0.001) and depression (P < 0.001). Depression was 1.3 (95% CI: 1.12, 1.96) times more likely in patients with moderate pain and 2.0 (95% CI: 1.56, 2.46) times more likely in patients with extreme pain. Conclusions Moderate to extreme pain was present in 57.8% of diabetic patients. Pain was strongly associated with poorer mental health and physical functioning, but not worse glycaemic control. Recognizing the high prevalence of pain and its strong association with poorer health-related quality of life may be important to improve the comprehensive management of diabetes.

KW - Depression

KW - Diabetes mellitus

KW - Glycaemic control

KW - Pain

KW - Quality of life

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