Prevalence rates for dementia and Alzheimer's disease in African Americans: 1992 versus 2001

Kathleen S. Hall, Sujuan Gao, Olusegun Baiyewu, Kathleen A. Lane, Oye Gureje, Jianzhao Shen, Adesola Ogunniyi, Jill R. Murrell, Frederick W. Unverzagt, Jeanne Dickens, Valerie Smith-Gamble, Hugh C. Hendrie

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Background: This study compares age-specific and overall prevalence rates for dementia and Alzheimer's disease (AD) in two nonoverlapping, population-based cohorts of elderly African Americans in Indianapolis in 2001 and 1992. Methods: We used a two-stage design. The first stage involves the Community Screening Interview for Dementia (CSI-D). The CSI-D scores are grouped into good, intermediate, and poor performance before selection for clinical assessment. Diagnoses were performed using standard criteria in a consensus diagnosis conference; clinicians were blind to performance groups. In 1992, interviewers visited randomly sampled addresses to enroll self-identified African Americans aged ≥65 years. Of 2582 eligible, 2212 enrolled (9.6% refused, and 4.7% were too sick). In 2001, Medicare rolls were used for African Americans aged >70 years. Of 4260 eligible, 1892 (44%) enrolled, 1999 (47%) refused, and the remainder did not participate for other reasons. Results: The overall age-adjusted prevalence rate for dementia at age ≥70 years in 2001 was 7.45% (95 confidence interval [CI], 4.27-10.64), and in the 1992 cohort, this prevalence rate was 6.75% (95% CI, 5.77-7.74). The overall age-adjusted prevalence rate at age ≥70 years for AD in the 2001 cohort was 6.77% (95% CI, 3.65-9.90), and for the 1992 cohort, it was 5.47% (95% CI, 4.51-6.42). Rates for dementia and AD were not significantly different in the two cohorts (dementia, P = .3534; AD, P = .2649). Conclusions: We found no differences in the prevalence rates of dementia and AD between 1992 and 2001, despite significant differences in medical history and medical treatment within these population-based cohorts of African American elderly.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalAlzheimer's and Dementia
Volume5
Issue number3
DOIs
StatePublished - May 1 2009

Keywords

  • 1992 vs 2001
  • African Americans
  • Alzheimer's disease
  • Population-based
  • Prevalence rates

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

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