Prevention of allogeneic fetal rejection by tryptophan catabolism

David H. Munn, Min Zhou, John T. Attwood, Igor Bondarev, Simon Conway, Brendan Marshall, Corrie Brown, Andrew L. Mellor

Research output: Contribution to journalArticle

1834 Citations (Scopus)

Abstract

In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell-induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection.

Original languageEnglish (US)
Pages (from-to)1191-1193
Number of pages3
JournalScience
Volume281
Issue number5380
StatePublished - Aug 21 1998
Externally publishedYes

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Tryptophan
Indoleamine-Pyrrole 2,3,-Dioxygenase
T-Lymphocytes
Tissue Transplantation
Trophoblasts
Macrophages
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Munn, D. H., Zhou, M., Attwood, J. T., Bondarev, I., Conway, S., Marshall, B., ... Mellor, A. L. (1998). Prevention of allogeneic fetal rejection by tryptophan catabolism. Science, 281(5380), 1191-1193.

Prevention of allogeneic fetal rejection by tryptophan catabolism. / Munn, David H.; Zhou, Min; Attwood, John T.; Bondarev, Igor; Conway, Simon; Marshall, Brendan; Brown, Corrie; Mellor, Andrew L.

In: Science, Vol. 281, No. 5380, 21.08.1998, p. 1191-1193.

Research output: Contribution to journalArticle

Munn, DH, Zhou, M, Attwood, JT, Bondarev, I, Conway, S, Marshall, B, Brown, C & Mellor, AL 1998, 'Prevention of allogeneic fetal rejection by tryptophan catabolism', Science, vol. 281, no. 5380, pp. 1191-1193.
Munn DH, Zhou M, Attwood JT, Bondarev I, Conway S, Marshall B et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998 Aug 21;281(5380):1191-1193.
Munn, David H. ; Zhou, Min ; Attwood, John T. ; Bondarev, Igor ; Conway, Simon ; Marshall, Brendan ; Brown, Corrie ; Mellor, Andrew L. / Prevention of allogeneic fetal rejection by tryptophan catabolism. In: Science. 1998 ; Vol. 281, No. 5380. pp. 1191-1193.
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