Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack

Jason S. Day, Bruno A. Policeni, Wendy R.K. Smoker, Mircea C. Dobre, Ying Zhang, Enrique C. Leira, Patricia H. Davis, Sherman Chen, Heena Olalde, Harold P. Adams

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and Purpose- Microhemorrhages on gradient-echo T2*-weighted MRI sequences are often found in patients with cerebrovascular disease and are related to intracerebral hemorrhage. Because statin therapy is associated with increased risk of intracerebral hemorrhage, we investigated whether statin use was also associated with microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. Methods- We performed a retrospective analysis on prospectively collected data from a stroke registry containing patients with acute ischemic stroke or transient ischemic attack. The primary and secondary outcome variables were the prevalence and degree of microhemorrhages as detected on gradient-echo MRI sequences and categorized as mild (1-2), moderate (3-10), or severe (>10). The location of the microhemorrhages was noted and rated by 2 neuroradiologists. Previous use of statins and other covariates were assessed as potential predictors. Results- Three hundred forty-nine patients were admitted from June 2008 to July 2009, and 300 of which were analyzed. Microhemorrhages were detected in 70 subjects (23%); 35 had only lobar lesions, 16 had only deep lesions, and 19 had both lobar and deep lesions. On univariate and multivariate analysis, statin therapy was not associated with the prevalence (OR, 0.73; 95% CI, 0.36-1.51; P=0.40) or degree of microhemorrhages modeled for lesser severity (OR, 2.31; 95% CI, 0.61-8.75; P=0.22). Conclusions- Previous statin therapy was not associated with the prevalence or degree of microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. The association between statins and intracerebral hemorrhage does not appear to be mediated through microhemorrhages.

Original languageEnglish (US)
Pages (from-to)354-358
Number of pages5
JournalStroke
Volume42
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Transient Ischemic Attack
Stroke
Cerebral Hemorrhage
Cerebrovascular Disorders
Registries
Therapeutics
Multivariate Analysis

Keywords

  • gradient-echo
  • microangiopathy
  • microbleed
  • microhemorrhage
  • statin

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack. / Day, Jason S.; Policeni, Bruno A.; Smoker, Wendy R.K.; Dobre, Mircea C.; Zhang, Ying; Leira, Enrique C.; Davis, Patricia H.; Chen, Sherman; Olalde, Heena; Adams, Harold P.

In: Stroke, Vol. 42, No. 2, 01.02.2011, p. 354-358.

Research output: Contribution to journalArticle

Day, Jason S. ; Policeni, Bruno A. ; Smoker, Wendy R.K. ; Dobre, Mircea C. ; Zhang, Ying ; Leira, Enrique C. ; Davis, Patricia H. ; Chen, Sherman ; Olalde, Heena ; Adams, Harold P. / Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack. In: Stroke. 2011 ; Vol. 42, No. 2. pp. 354-358.
@article{ef1188e87e6243ff883e835ff81415b5,
title = "Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack",
abstract = "Background and Purpose- Microhemorrhages on gradient-echo T2*-weighted MRI sequences are often found in patients with cerebrovascular disease and are related to intracerebral hemorrhage. Because statin therapy is associated with increased risk of intracerebral hemorrhage, we investigated whether statin use was also associated with microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. Methods- We performed a retrospective analysis on prospectively collected data from a stroke registry containing patients with acute ischemic stroke or transient ischemic attack. The primary and secondary outcome variables were the prevalence and degree of microhemorrhages as detected on gradient-echo MRI sequences and categorized as mild (1-2), moderate (3-10), or severe (>10). The location of the microhemorrhages was noted and rated by 2 neuroradiologists. Previous use of statins and other covariates were assessed as potential predictors. Results- Three hundred forty-nine patients were admitted from June 2008 to July 2009, and 300 of which were analyzed. Microhemorrhages were detected in 70 subjects (23{\%}); 35 had only lobar lesions, 16 had only deep lesions, and 19 had both lobar and deep lesions. On univariate and multivariate analysis, statin therapy was not associated with the prevalence (OR, 0.73; 95{\%} CI, 0.36-1.51; P=0.40) or degree of microhemorrhages modeled for lesser severity (OR, 2.31; 95{\%} CI, 0.61-8.75; P=0.22). Conclusions- Previous statin therapy was not associated with the prevalence or degree of microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. The association between statins and intracerebral hemorrhage does not appear to be mediated through microhemorrhages.",
keywords = "gradient-echo, microangiopathy, microbleed, microhemorrhage, statin",
author = "Day, {Jason S.} and Policeni, {Bruno A.} and Smoker, {Wendy R.K.} and Dobre, {Mircea C.} and Ying Zhang and Leira, {Enrique C.} and Davis, {Patricia H.} and Sherman Chen and Heena Olalde and Adams, {Harold P.}",
year = "2011",
month = "2",
day = "1",
doi = "10.1161/STROKEAHA.110.594101",
language = "English (US)",
volume = "42",
pages = "354--358",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack

AU - Day, Jason S.

AU - Policeni, Bruno A.

AU - Smoker, Wendy R.K.

AU - Dobre, Mircea C.

AU - Zhang, Ying

AU - Leira, Enrique C.

AU - Davis, Patricia H.

AU - Chen, Sherman

AU - Olalde, Heena

AU - Adams, Harold P.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background and Purpose- Microhemorrhages on gradient-echo T2*-weighted MRI sequences are often found in patients with cerebrovascular disease and are related to intracerebral hemorrhage. Because statin therapy is associated with increased risk of intracerebral hemorrhage, we investigated whether statin use was also associated with microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. Methods- We performed a retrospective analysis on prospectively collected data from a stroke registry containing patients with acute ischemic stroke or transient ischemic attack. The primary and secondary outcome variables were the prevalence and degree of microhemorrhages as detected on gradient-echo MRI sequences and categorized as mild (1-2), moderate (3-10), or severe (>10). The location of the microhemorrhages was noted and rated by 2 neuroradiologists. Previous use of statins and other covariates were assessed as potential predictors. Results- Three hundred forty-nine patients were admitted from June 2008 to July 2009, and 300 of which were analyzed. Microhemorrhages were detected in 70 subjects (23%); 35 had only lobar lesions, 16 had only deep lesions, and 19 had both lobar and deep lesions. On univariate and multivariate analysis, statin therapy was not associated with the prevalence (OR, 0.73; 95% CI, 0.36-1.51; P=0.40) or degree of microhemorrhages modeled for lesser severity (OR, 2.31; 95% CI, 0.61-8.75; P=0.22). Conclusions- Previous statin therapy was not associated with the prevalence or degree of microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. The association between statins and intracerebral hemorrhage does not appear to be mediated through microhemorrhages.

AB - Background and Purpose- Microhemorrhages on gradient-echo T2*-weighted MRI sequences are often found in patients with cerebrovascular disease and are related to intracerebral hemorrhage. Because statin therapy is associated with increased risk of intracerebral hemorrhage, we investigated whether statin use was also associated with microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. Methods- We performed a retrospective analysis on prospectively collected data from a stroke registry containing patients with acute ischemic stroke or transient ischemic attack. The primary and secondary outcome variables were the prevalence and degree of microhemorrhages as detected on gradient-echo MRI sequences and categorized as mild (1-2), moderate (3-10), or severe (>10). The location of the microhemorrhages was noted and rated by 2 neuroradiologists. Previous use of statins and other covariates were assessed as potential predictors. Results- Three hundred forty-nine patients were admitted from June 2008 to July 2009, and 300 of which were analyzed. Microhemorrhages were detected in 70 subjects (23%); 35 had only lobar lesions, 16 had only deep lesions, and 19 had both lobar and deep lesions. On univariate and multivariate analysis, statin therapy was not associated with the prevalence (OR, 0.73; 95% CI, 0.36-1.51; P=0.40) or degree of microhemorrhages modeled for lesser severity (OR, 2.31; 95% CI, 0.61-8.75; P=0.22). Conclusions- Previous statin therapy was not associated with the prevalence or degree of microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. The association between statins and intracerebral hemorrhage does not appear to be mediated through microhemorrhages.

KW - gradient-echo

KW - microangiopathy

KW - microbleed

KW - microhemorrhage

KW - statin

UR - http://www.scopus.com/inward/record.url?scp=79251642436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251642436&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.110.594101

DO - 10.1161/STROKEAHA.110.594101

M3 - Article

VL - 42

SP - 354

EP - 358

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 2

ER -