Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack

Jason S. Day, Bruno A. Policeni, Wendy R.K. Smoker, Mircea C. Dobre, Ying Zhang, Enrique C. Leira, Patricia H. Davis, Sherman Chen, Heena Olalde, Harold P. Adams

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background and Purpose- Microhemorrhages on gradient-echo T2*-weighted MRI sequences are often found in patients with cerebrovascular disease and are related to intracerebral hemorrhage. Because statin therapy is associated with increased risk of intracerebral hemorrhage, we investigated whether statin use was also associated with microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. Methods- We performed a retrospective analysis on prospectively collected data from a stroke registry containing patients with acute ischemic stroke or transient ischemic attack. The primary and secondary outcome variables were the prevalence and degree of microhemorrhages as detected on gradient-echo MRI sequences and categorized as mild (1-2), moderate (3-10), or severe (>10). The location of the microhemorrhages was noted and rated by 2 neuroradiologists. Previous use of statins and other covariates were assessed as potential predictors. Results- Three hundred forty-nine patients were admitted from June 2008 to July 2009, and 300 of which were analyzed. Microhemorrhages were detected in 70 subjects (23%); 35 had only lobar lesions, 16 had only deep lesions, and 19 had both lobar and deep lesions. On univariate and multivariate analysis, statin therapy was not associated with the prevalence (OR, 0.73; 95% CI, 0.36-1.51; P=0.40) or degree of microhemorrhages modeled for lesser severity (OR, 2.31; 95% CI, 0.61-8.75; P=0.22). Conclusions- Previous statin therapy was not associated with the prevalence or degree of microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. The association between statins and intracerebral hemorrhage does not appear to be mediated through microhemorrhages.

Original languageEnglish (US)
Pages (from-to)354-358
Number of pages5
JournalStroke
Volume42
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Keywords

  • gradient-echo
  • microangiopathy
  • microbleed
  • microhemorrhage
  • statin

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Day, J. S., Policeni, B. A., Smoker, W. R. K., Dobre, M. C., Zhang, Y., Leira, E. C., Davis, P. H., Chen, S., Olalde, H., & Adams, H. P. (2011). Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack. Stroke, 42(2), 354-358. https://doi.org/10.1161/STROKEAHA.110.594101