Primary breast tumor characteristics predicting aggressive nodal involvement

Aye Moe Thu Ma, Monet Bowling, Marilyn Leitch, Roshni Rao, David M. Euhus

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: pN3 breast cancer is historically associated with a poor prognosis, but the biology of aggressive nodal involvement or lymphatotropism is not well understood. Methods: This retrospective study compares clinical and pathological features for 1347 breast cancer patients with pN0 disease, 560 with pN1 disease, and 100 with ≥10 positive nodes (pN3 [10] disease). Results: Compared with pN1 disease, pN3 (10) disease was more frequently associated with T3-4 primaries (9% versus 38%, P ≤ .001), lobular histology (11% versus 22%, P = .01), and inflammatory cancer (1% versus 5%, P = 0.01). pN3 (10) disease was not associated with early-onset or estrogen receptor-negative breast cancer. The 5- and 10-year overall survival for pN3 (10) patients was 64% and 21%, respectively. Conclusions: The data indicates that the prognosis for pN3 (10) patients may be improving with current treatment. Molecular pathways governing aggressive lymphatotropism appear to be independent of those associated with early-onset, estrogen receptor-negative breast cancer.

Original languageEnglish (US)
Pages (from-to)474-476
Number of pages3
JournalAmerican Journal of Surgery
Volume194
Issue number4
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Breast Neoplasms
Estrogen Receptors
Histology
Retrospective Studies
Survival
Neoplasms
Therapeutics

Keywords

  • 10 axillary lymph nodes
  • Breast neoplasms/mortality
  • Breast neoplasms/pathology
  • Carcinoma/mortality
  • Lymphatic metastasis
  • Prognosis
  • Survival rate

ASJC Scopus subject areas

  • Surgery

Cite this

Primary breast tumor characteristics predicting aggressive nodal involvement. / Ma, Aye Moe Thu; Bowling, Monet; Leitch, Marilyn; Rao, Roshni; Euhus, David M.

In: American Journal of Surgery, Vol. 194, No. 4, 10.2007, p. 474-476.

Research output: Contribution to journalArticle

Ma, Aye Moe Thu ; Bowling, Monet ; Leitch, Marilyn ; Rao, Roshni ; Euhus, David M. / Primary breast tumor characteristics predicting aggressive nodal involvement. In: American Journal of Surgery. 2007 ; Vol. 194, No. 4. pp. 474-476.
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