Primary hepatic B-cell lymphoma in a child

M. H. Collins, A. Orazi, M. Bauman, Terry Vik, K. West, N. A. Heerema, E. Klatte, R. S. Neiman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Lymphoma arising in the liver is uncommon in adults and rare in children. A 12-year-old boy with hepatomegaly and jaundice had a calcified intrahepatic large-cell lymphoma of B-cell origin that expressed bcl-2 protein and had near-tetraploid chromosome number with a t(8;14) (q24;q32) and a homogeneously staining region (HSR). This tumor, only the fourth example of primary hepatic lymphoma in a child, has the rare finding of an HSR before treatment and is the first human lymphoma with t(8;14) that expresses bcl-2 protein. In addition, the demonstration of extensive calcification in the tumor by computed tomography scan is highly unusual for lymphoma. Lymphoma must be considered in the differential diagnosis of primary liver tumors in children and adults, especially if the serum alpha-fetoprotein level is normal.

Original languageEnglish
Pages (from-to)1182-1186
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume17
Issue number11
DOIs
StatePublished - 1993

Fingerprint

B-Cell Lymphoma
Hepatocytes
Lymphoma
Liver
Staining and Labeling
Neoplasms
Tetraploidy
Hepatomegaly
alpha-Fetoproteins
Jaundice
Proteins
Differential Diagnosis
Chromosomes
Tomography
Serum

Keywords

  • bcl-2 protein
  • Chromosomes
  • Cytogenetics
  • Diffuse large cell
  • Ho mogeneously Staining Region
  • Liver
  • Lymphoma
  • Pathology
  • Pediatrics
  • Translocation
  • Ultrastructure

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Collins, M. H., Orazi, A., Bauman, M., Vik, T., West, K., Heerema, N. A., ... Neiman, R. S. (1993). Primary hepatic B-cell lymphoma in a child. American Journal of Surgical Pathology, 17(11), 1182-1186. https://doi.org/10.1097/00000478-199311000-00012

Primary hepatic B-cell lymphoma in a child. / Collins, M. H.; Orazi, A.; Bauman, M.; Vik, Terry; West, K.; Heerema, N. A.; Klatte, E.; Neiman, R. S.

In: American Journal of Surgical Pathology, Vol. 17, No. 11, 1993, p. 1182-1186.

Research output: Contribution to journalArticle

Collins, MH, Orazi, A, Bauman, M, Vik, T, West, K, Heerema, NA, Klatte, E & Neiman, RS 1993, 'Primary hepatic B-cell lymphoma in a child', American Journal of Surgical Pathology, vol. 17, no. 11, pp. 1182-1186. https://doi.org/10.1097/00000478-199311000-00012
Collins, M. H. ; Orazi, A. ; Bauman, M. ; Vik, Terry ; West, K. ; Heerema, N. A. ; Klatte, E. ; Neiman, R. S. / Primary hepatic B-cell lymphoma in a child. In: American Journal of Surgical Pathology. 1993 ; Vol. 17, No. 11. pp. 1182-1186.
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