Primary hepatic B-cell lymphoma in a child

M. H. Collins, A. Orazi, M. Bauman, T. Vik, K. West, N. A. Heerema, E. Klatte, R. S. Neiman

Research output: Contribution to journalArticle

18 Scopus citations


Lymphoma arising in the liver is uncommon in adults and rare in children. A 12-year-old boy with hepatomegaly and jaundice had a calcified intrahepatic large-cell lymphoma of B-cell origin that expressed bcl-2 protein and had near-tetraploid chromosome number with a t(8;14) (q24;q32) and a homogeneously staining region (HSR). This tumor, only the fourth example of primary hepatic lymphoma in a child, has the rare finding of an HSR before treatment and is the first human lymphoma with t(8;14) that expresses bcl-2 protein. In addition, the demonstration of extensive calcification in the tumor by computed tomography scan is highly unusual for lymphoma. Lymphoma must be considered in the differential diagnosis of primary liver tumors in children and adults, especially if the serum alpha-fetoprotein level is normal.

Original languageEnglish (US)
Pages (from-to)1182-1186
Number of pages5
JournalAmerican Journal of Surgical Pathology
Issue number11
StatePublished - Nov 5 1993


  • bcl-2 protein
  • Chromosomes
  • Cytogenetics
  • Diffuse large cell
  • Ho mogeneously Staining Region
  • Liver
  • Lymphoma
  • Pathology
  • Pediatrics
  • Translocation
  • Ultrastructure

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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    Collins, M. H., Orazi, A., Bauman, M., Vik, T., West, K., Heerema, N. A., Klatte, E., & Neiman, R. S. (1993). Primary hepatic B-cell lymphoma in a child. American Journal of Surgical Pathology, 17(11), 1182-1186.