Primary Hyperparathyroidism and the Kidney

Munro Peacock

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The kidney occupies a unique position in primary hyperparathyroidism (PHPT). It is largely responsible for setting the concentration of calcium and phosphate in extracellular fluid and determining active transport of dietary calcium and phosphate. It does so by virtue of the action of PTH on the renal tubule to regulate reabsorption of calcium and phosphate, and to control the secretion rate of 1,25-dihydroxyvitamin D. Measurement of calcium and phosphate processing by the kidney is essential for diagnosis and management of PHPT. Hypercalcemia with hyperparathyroidemia is the diagnostic biochemical feature of PHPT. Drugs acting on the kidney and chronic renal failure modify the serum biochemical and tissue manifestations of the disease. The kidney is one of the few organs that unequivocally manifest primary hyperparathyroid disease clinically. Abnormalities in urinary and pre-urinary risk factors in PHPT increase the risk of recurrent renal stone formation and nephrocalcinosis.

Original languageEnglish (US)
Title of host publicationThe Parathyroids
Subtitle of host publicationBasic and Clinical Concepts: Third Edition
PublisherElsevier Inc.
Pages455-467
Number of pages13
ISBN (Print)9780123971661
DOIs
StatePublished - Jan 1 2015

Keywords

  • 1,25-dihydroxyvitamin D
  • Fibroblast growth factor 23
  • Nephrocalcinosis
  • Parathyroid hormone
  • Renal stone
  • Renal tubular calcium reabsorption
  • Renal tubular phosphate reabsorption
  • Urine calcium
  • Urine phosphate

ASJC Scopus subject areas

  • Medicine(all)

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    Peacock, M. (2015). Primary Hyperparathyroidism and the Kidney. In The Parathyroids: Basic and Clinical Concepts: Third Edition (pp. 455-467). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397166-1.00031-X