Primary hyperparathyroidism associated with primary hyperaldosteronism

J. B. Ferriss, J. J. Brown, A. M.M. Cumming, R. Fraser, A. F. Lever, M. Peacock, J. I. Robertson

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Abstract

Two patients with both primary hyperparathyroidism and primary hyperaldosteronism are described. Each presented with high blood pressure and a history of renal calculi. Mild hypercalcaemia was associated with raised plasma parathyroid hormone concentrations and a parathyroid adenoma was excised from each. Both patients also had hypokalaemia, hyperaldosteronism and low plasma renin concentrations. Quadric analysis, adrenal vein plasma aldosterone concentrations, adrenal venography and CT scanning all suggested an adrenal adenoma in each patient; the other patient is unfit for adrenal surgery but her blood pressure and plasma potassium concentration have remained within the normal range during prolonged treatment with either spironolactone or amiloride. Because of this unusual association a search was made for parathyroid hormone excess in patients with primary hyperaldosteronism and for aldosterone excess in primary hyperparathyroidism. None was found.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalActa Endocrinologica
Volume103
Issue number3
StatePublished - Aug 18 1983

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ASJC Scopus subject areas

  • Endocrinology

Cite this

Ferriss, J. B., Brown, J. J., Cumming, A. M. M., Fraser, R., Lever, A. F., Peacock, M., & Robertson, J. I. (1983). Primary hyperparathyroidism associated with primary hyperaldosteronism. Acta Endocrinologica, 103(3), 365-370.