Primary osteosarcoma of the kidney

Report of a case studied by immunohistochemistry, electron microscopy, and DNA flow cytometry

F. P. O'Malley, David Grignon, R. R. Shepherd, L. A. Harker

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A case of primary osteogenic sarcoma of the kidney is presented. The patient, a 75-year-old man, presented with flank pain, weight loss, and a lower lip lesion. Biopsy of the lip lesion showed metastatic sarcoma and nephrectomy revealed a primary osteogenic sarcoma. Ultrastructural and immunohistochemical studies confirmed the mesenchymal nature of the lesion and helped exclude sarcomatoid renal cell carcinoma from the differential diagnosis. Multiple samples of the primary tumor and metastatic deposits analyzed by DNA flow cytometry all showed a diploid DNA content. Clinically the tumor has pursued a slowly progressive course, with metastases.

Original languageEnglish (US)
Pages (from-to)1262-1265
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume115
Issue number12
StatePublished - 1991
Externally publishedYes

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Osteosarcoma
Lip
Electron Microscopy
Flow Cytometry
Immunohistochemistry
Kidney
Flank Pain
DNA
Nephrectomy
Diploidy
Renal Cell Carcinoma
Sarcoma
Weight Loss
Neoplasms
Differential Diagnosis
Neoplasm Metastasis
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Primary osteosarcoma of the kidney : Report of a case studied by immunohistochemistry, electron microscopy, and DNA flow cytometry. / O'Malley, F. P.; Grignon, David; Shepherd, R. R.; Harker, L. A.

In: Archives of Pathology and Laboratory Medicine, Vol. 115, No. 12, 1991, p. 1262-1265.

Research output: Contribution to journalArticle

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