Primary pulmonary hypertension between inflammation and cancer

N. F. Voelkel, C. Cool, S. D. Lee, L. Wright, M. W. Geraci, R. M. Tuder

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

We believe that the monoclonal cell expansion in primary pulmonary hypertension is the result of autonomous growth of stem cell-like endothelial cells, whereas the polyclonal proliferation in secondary pulmonary hypertension occurs as a response of endothelial cells to exogenous stimuli (like vital infection or high shear stress). In this context, we propose that different transcriptional and translational events govern the growth and expansion of monoclonal when compared with polyclonal pulmonary endothelial cells. The availability of antibodies directed against specific tyrosine kinase proteins involved in vasculogenesis/angiogenesis now permits the identification and localization of the components of such a misguided angiogenesis cell proliferation program in the pulmonary hypertensive vascular lesions.

Original languageEnglish (US)
JournalChest
Volume114
Issue number3 SUPPL.
StatePublished - 1998
Externally publishedYes

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Endothelial Cells
Inflammation
Neoplasms
Lung
Growth
Pulmonary Hypertension
Protein-Tyrosine Kinases
Blood Vessels
Stem Cells
Cell Proliferation
Antibodies
Infection
Familial Primary Pulmonary Hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Voelkel, N. F., Cool, C., Lee, S. D., Wright, L., Geraci, M. W., & Tuder, R. M. (1998). Primary pulmonary hypertension between inflammation and cancer. Chest, 114(3 SUPPL.).

Primary pulmonary hypertension between inflammation and cancer. / Voelkel, N. F.; Cool, C.; Lee, S. D.; Wright, L.; Geraci, M. W.; Tuder, R. M.

In: Chest, Vol. 114, No. 3 SUPPL., 1998.

Research output: Contribution to journalArticle

Voelkel, NF, Cool, C, Lee, SD, Wright, L, Geraci, MW & Tuder, RM 1998, 'Primary pulmonary hypertension between inflammation and cancer', Chest, vol. 114, no. 3 SUPPL..
Voelkel NF, Cool C, Lee SD, Wright L, Geraci MW, Tuder RM. Primary pulmonary hypertension between inflammation and cancer. Chest. 1998;114(3 SUPPL.).
Voelkel, N. F. ; Cool, C. ; Lee, S. D. ; Wright, L. ; Geraci, M. W. ; Tuder, R. M. / Primary pulmonary hypertension between inflammation and cancer. In: Chest. 1998 ; Vol. 114, No. 3 SUPPL.
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