Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8

T. M. Bull, C. D. Cool, A. E. Serls, P. R. Rai, J. Parr, J. M. Neid, M. W. Geraci, T. B. Campbell, N. F. Voelkel, D. B. Badesch

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40 Scopus citations


Primary pulmonary hypertension (PPH) and Castleman's disease (CD) are rare conditions infrequently encountered in clinical practice. In this paper, two patients diagnosed with both of these diseases are reported. The authors speculate that rather than being a chance occurrence, these conditions are linked by a common angio-proliferative mechanism. Therefore, an association between infection with the human herpesvirus-8 and the diseases of PPH and CD was sought. Evidence of human herpesvirus-8 infection was found in the lung tissue and, specifically, in the plexiform lesions from one of the patients.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalEuropean Respiratory Journal
Issue number3
StatePublished - Sep 1 2003


  • Endothelial cell
  • Human herpesvirus-8
  • Plexiform lesion
  • Primary pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Bull, T. M., Cool, C. D., Serls, A. E., Rai, P. R., Parr, J., Neid, J. M., Geraci, M. W., Campbell, T. B., Voelkel, N. F., & Badesch, D. B. (2003). Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8. European Respiratory Journal, 22(3), 403-407.