Primary renal extra-osseous osteosarcoma

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Primary renal extra-osseous osteosarcoma is an exceedingly rare and deadly kidney neoplasm with only 27 reported cases to date. Extra-osseous osteosarcoma is a mesenchymal sarcoma that produces osteoid, but has no skeletal or periosteal involvement and most commonly arises in the lower extremities. Yet, it can arise in other locations such as the kidney. Extra-osseous osteosarcoma behaves as a separate entity from osseous osteosarcoma and should be treated as such. The treatment is surgical resection. Five year overall survival is 46% for local and 10% for metastatic disease. Additionally, 45%-50% of patients experience disease recurrence. We present a 77-year-old woman who underwent work up for recurrent gross hematuria and subsequently underwent radical nephroureterectomy for presumed upper tract urothelial cell carcinoma. However, pathologic analysis revealed a diagnosis of primary renal extra-osseous osteosarcoma. She is alive with no evidence of disease 30 months after surgery.

Original languageEnglish
Pages (from-to)7929-7931
Number of pages3
JournalCanadian Journal of Urology
Volume22
Issue number4
StatePublished - 2015

Fingerprint

Osteosarcoma
Kidney
Kidney Neoplasms
Hematuria
Sarcoma
Lower Extremity
Carcinoma
Recurrence
Survival

Keywords

  • Kidney cancer
  • Nephrectomy
  • Osteosarcoma
  • Prognosis
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Urology

Cite this

Primary renal extra-osseous osteosarcoma. / Flynn, Kevin J.; Kaimakliotis, Hristos; Cheng, Liang; Sundaram, Chandru.

In: Canadian Journal of Urology, Vol. 22, No. 4, 2015, p. 7929-7931.

Research output: Contribution to journalArticle

@article{1cffc2df6d424c57bd3731052ab57769,
title = "Primary renal extra-osseous osteosarcoma",
abstract = "Primary renal extra-osseous osteosarcoma is an exceedingly rare and deadly kidney neoplasm with only 27 reported cases to date. Extra-osseous osteosarcoma is a mesenchymal sarcoma that produces osteoid, but has no skeletal or periosteal involvement and most commonly arises in the lower extremities. Yet, it can arise in other locations such as the kidney. Extra-osseous osteosarcoma behaves as a separate entity from osseous osteosarcoma and should be treated as such. The treatment is surgical resection. Five year overall survival is 46{\%} for local and 10{\%} for metastatic disease. Additionally, 45{\%}-50{\%} of patients experience disease recurrence. We present a 77-year-old woman who underwent work up for recurrent gross hematuria and subsequently underwent radical nephroureterectomy for presumed upper tract urothelial cell carcinoma. However, pathologic analysis revealed a diagnosis of primary renal extra-osseous osteosarcoma. She is alive with no evidence of disease 30 months after surgery.",
keywords = "Kidney cancer, Nephrectomy, Osteosarcoma, Prognosis, Soft tissue sarcoma",
author = "Flynn, {Kevin J.} and Hristos Kaimakliotis and Liang Cheng and Chandru Sundaram",
year = "2015",
language = "English",
volume = "22",
pages = "7929--7931",
journal = "Canadian Journal of Urology",
issn = "1195-9479",
publisher = "Canadian Journal of Urology",
number = "4",

}

TY - JOUR

T1 - Primary renal extra-osseous osteosarcoma

AU - Flynn, Kevin J.

AU - Kaimakliotis, Hristos

AU - Cheng, Liang

AU - Sundaram, Chandru

PY - 2015

Y1 - 2015

N2 - Primary renal extra-osseous osteosarcoma is an exceedingly rare and deadly kidney neoplasm with only 27 reported cases to date. Extra-osseous osteosarcoma is a mesenchymal sarcoma that produces osteoid, but has no skeletal or periosteal involvement and most commonly arises in the lower extremities. Yet, it can arise in other locations such as the kidney. Extra-osseous osteosarcoma behaves as a separate entity from osseous osteosarcoma and should be treated as such. The treatment is surgical resection. Five year overall survival is 46% for local and 10% for metastatic disease. Additionally, 45%-50% of patients experience disease recurrence. We present a 77-year-old woman who underwent work up for recurrent gross hematuria and subsequently underwent radical nephroureterectomy for presumed upper tract urothelial cell carcinoma. However, pathologic analysis revealed a diagnosis of primary renal extra-osseous osteosarcoma. She is alive with no evidence of disease 30 months after surgery.

AB - Primary renal extra-osseous osteosarcoma is an exceedingly rare and deadly kidney neoplasm with only 27 reported cases to date. Extra-osseous osteosarcoma is a mesenchymal sarcoma that produces osteoid, but has no skeletal or periosteal involvement and most commonly arises in the lower extremities. Yet, it can arise in other locations such as the kidney. Extra-osseous osteosarcoma behaves as a separate entity from osseous osteosarcoma and should be treated as such. The treatment is surgical resection. Five year overall survival is 46% for local and 10% for metastatic disease. Additionally, 45%-50% of patients experience disease recurrence. We present a 77-year-old woman who underwent work up for recurrent gross hematuria and subsequently underwent radical nephroureterectomy for presumed upper tract urothelial cell carcinoma. However, pathologic analysis revealed a diagnosis of primary renal extra-osseous osteosarcoma. She is alive with no evidence of disease 30 months after surgery.

KW - Kidney cancer

KW - Nephrectomy

KW - Osteosarcoma

KW - Prognosis

KW - Soft tissue sarcoma

UR - http://www.scopus.com/inward/record.url?scp=84939172796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939172796&partnerID=8YFLogxK

M3 - Article

C2 - 26267034

AN - SCOPUS:84939172796

VL - 22

SP - 7929

EP - 7931

JO - Canadian Journal of Urology

JF - Canadian Journal of Urology

SN - 1195-9479

IS - 4

ER -