Primary renal osteosarcoma

Antonio Lopez-Beltran, Rodolfo Montironi, Jose L. Carazo, Alfredo Vidal, Liang Cheng

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objectives: To investigate primary osteosarcoma (osteogenic sarcoma) of the kidney, a rare and aggressive neoplasm. Methods: We present clinical and pathologic features of three female patients, aged 50, 66, and 78 years, affected by primary osteosarcoma of the kidney. The diagnosis was made by H&E-stained samples from totally (cases 1 and 2) or partially (case 3) embedded tumors. Results: Reported cases showed histologic features of low-grade (n = 1), chondroblastic (n = 1), and osteoblastic (n = 1) osteosarcoma. Tumor size ranged from 3 to 7 cm, and pT category was pT1a (n = 1), pT1b (n = 1), and pT3a (n = 1). Immunohistochemistry gave focal positive results with PAX2 and CD10 in case 1 and S100 in case 2. On follow-up, two patients were disease free at 25 and 68 months and one died of metastases. Conclusions: Surgically treated primary renal osteosarcoma might not be as aggressive as previously thought if diagnosed early with low pT status.

Original languageEnglish (US)
Pages (from-to)747-752
Number of pages6
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - May 1 2014


  • Kidney
  • Osteogenic sarcoma
  • Osteosarcoma
  • Primary renal sarcoma
  • Soft tissue tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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