Primary renal osteosarcoma

Antonio Lopez-Beltran, Rodolfo Montironi, Jose L. Carazo, Alfredo Vidal, Liang Cheng

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: To investigate primary osteosarcoma (osteogenic sarcoma) of the kidney, a rare and aggressive neoplasm. Methods: We present clinical and pathologic features of three female patients, aged 50, 66, and 78 years, affected by primary osteosarcoma of the kidney. The diagnosis was made by H&E-stained samples from totally (cases 1 and 2) or partially (case 3) embedded tumors. Results: Reported cases showed histologic features of low-grade (n = 1), chondroblastic (n = 1), and osteoblastic (n = 1) osteosarcoma. Tumor size ranged from 3 to 7 cm, and pT category was pT1a (n = 1), pT1b (n = 1), and pT3a (n = 1). Immunohistochemistry gave focal positive results with PAX2 and CD10 in case 1 and S100 in case 2. On follow-up, two patients were disease free at 25 and 68 months and one died of metastases. Conclusions: Surgically treated primary renal osteosarcoma might not be as aggressive as previously thought if diagnosed early with low pT status.

Original languageEnglish
Pages (from-to)747-752
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume141
Issue number5
DOIs
StatePublished - May 1 2014

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Osteosarcoma
Kidney
Neoplasms
Immunohistochemistry
Neoplasm Metastasis

Keywords

  • Kidney
  • Osteogenic sarcoma
  • Osteosarcoma
  • Primary renal sarcoma
  • Soft tissue tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Lopez-Beltran, A., Montironi, R., Carazo, J. L., Vidal, A., & Cheng, L. (2014). Primary renal osteosarcoma. American Journal of Clinical Pathology, 141(5), 747-752. https://doi.org/10.1309/AJCPM86FVHAMWJSR

Primary renal osteosarcoma. / Lopez-Beltran, Antonio; Montironi, Rodolfo; Carazo, Jose L.; Vidal, Alfredo; Cheng, Liang.

In: American Journal of Clinical Pathology, Vol. 141, No. 5, 01.05.2014, p. 747-752.

Research output: Contribution to journalArticle

Lopez-Beltran, A, Montironi, R, Carazo, JL, Vidal, A & Cheng, L 2014, 'Primary renal osteosarcoma', American Journal of Clinical Pathology, vol. 141, no. 5, pp. 747-752. https://doi.org/10.1309/AJCPM86FVHAMWJSR
Lopez-Beltran A, Montironi R, Carazo JL, Vidal A, Cheng L. Primary renal osteosarcoma. American Journal of Clinical Pathology. 2014 May 1;141(5):747-752. https://doi.org/10.1309/AJCPM86FVHAMWJSR
Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Carazo, Jose L. ; Vidal, Alfredo ; Cheng, Liang. / Primary renal osteosarcoma. In: American Journal of Clinical Pathology. 2014 ; Vol. 141, No. 5. pp. 747-752.
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