Primary Sarcomas of the Lung

Rachel E. Sanborn, Adriana L. Gonzalez, Thomas M. Ulbright, Guru Sonpavde, Alan B. Sandler

Research output: Chapter in Book/Report/Conference proceedingChapter


Primary pulmonary sarcomas (PPSs) are a rare group of pulmonary malignancies, outnumbered by bronchogenic carcinomas by a factor of 500:1. These tumors are often difficult to differentiate and characterize on the basis of morphology alone, and diagnosis frequently depends on immunohistochemical and ultrastructural analysis. PPSs are typically very advanced at the time of diagnosis, with symptoms relating to tumor invasion or postobstructive pneumonia commonly prompting evaluation. Some patients, however, are asymptomatic at the time of diagnosis, with an incidental finding on an imaging study. Clinical symptoms and radiographic findings can resemble a diverse collection of other disease entities; thus, PPS needs to be entertained in the differential diagnosis in the evaluation of other diseases. Complete surgical resection remains the only approach for cure, although many patients are not eligible for resection at the time of diagnosis. Chemotherapy and radiation therapy play only limited roles in treatment, and newer, more efficacious, therapeutic agents are needed.

Original languageEnglish (US)
Title of host publicationTextbook of Uncommon Cancer, Third Edition
PublisherJohn Wiley & Sons, Ltd
Number of pages15
ISBN (Print)0470012021, 9780470012024
StatePublished - Jul 11 2006


  • Angiosarcoma
  • Epithelioid hemangioendothelioma
  • Fibrosarcoma
  • Hemangiopericytoma
  • Kaposi's sarcoma
  • Leiomyosarcoma
  • Malignant fibrous histiocytoma
  • Pulmonary sarcoma
  • Rhabdomyosarcoma
  • Synovial sarcoma

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sanborn, R. E., Gonzalez, A. L., Ulbright, T. M., Sonpavde, G., & Sandler, A. B. (2006). Primary Sarcomas of the Lung. In Textbook of Uncommon Cancer, Third Edition (pp. 264-278). John Wiley & Sons, Ltd.