Primary signet-ring cell carcinoma of the urinary bladder

David Grignon, J. Y. Ro, A. G. Ayala, D. E. Johnson

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Primary signet-ring cell carcinoma is an uncommon malignancy arising in the urinary bladder. The authors report 12 cases collected at their institution. Median age for the ten men and two women was 58 years; the most frequent presentation was hematuria. In two of nine cases no mucosal lesion was cystoscopically visible. Eleven tumors were of nonurachal origin and one of urachal. At diagnosis, one tumor was stage B, two stage C, seven stage D, and two stages unknown. Nine of 12 patients were dead of disease (range, 1-16 months; median, 9 months), 1 alive with metastatic disease, 1 alive and well, and 1 dead of an unrelated cause. From a literature review, the authors accepted 35 cases that met their criteria and combined them with their 12 cases for statistical analysis. Prognosis was worse with a pure diffuse versus a mixed tumor (P = 0.004) and for nonurachal versus urachal origin (P = 0.005). The difference in five-year survival rates between stages B and D disease (P <0.05) was also statistically significant.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume95
Issue number1
StatePublished - 1991
Externally publishedYes

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Signet Ring Cell Carcinoma
Urinary Bladder
Neoplasms
Hematuria
Survival Rate

Keywords

  • adenocarcinoma
  • signet-ring carcinoma
  • urinary bladder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Primary signet-ring cell carcinoma of the urinary bladder. / Grignon, David; Ro, J. Y.; Ayala, A. G.; Johnson, D. E.

In: American Journal of Clinical Pathology, Vol. 95, No. 1, 1991, p. 13-20.

Research output: Contribution to journalArticle

Grignon, D, Ro, JY, Ayala, AG & Johnson, DE 1991, 'Primary signet-ring cell carcinoma of the urinary bladder', American Journal of Clinical Pathology, vol. 95, no. 1, pp. 13-20.
Grignon, David ; Ro, J. Y. ; Ayala, A. G. ; Johnson, D. E. / Primary signet-ring cell carcinoma of the urinary bladder. In: American Journal of Clinical Pathology. 1991 ; Vol. 95, No. 1. pp. 13-20.
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