Primary Solid Tumors of the Colon and Rectum in the Pediatric Patient

A Review of 270 Cases

Relin Yang, Michael C. Cheung, Ying Zhuge, Christopher Armstrong, Leonidas Koniaris, Juan E. Sola

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To study the outcomes of solid tumors of the colon and rectum in pediatric patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1973-2005) was queried for patients less than 20 y of age. Results: Overall, 270 patients with malignant tumors of the lower gastrointestinal tract were identified. The annual incidence was 1.04 cases per million in 2005. Overall, equal distribution between boys (50.7%) and girls (49.3%) was observed. The majority of tumors arose in adolescents (68.1% were older than 15 y). Tumors were more commonly seen in white (77.8%) and non-Hispanic (78.9%) patients. Tumors were identified in the right colon (45.9%), transverse colon (9.3%), left colon (20.4%), rectum (15.2%), and anal canal (1.1%). The most common histology of these tumors was adenocarcinoma (35.6%), followed by carcinoid (34.1%). Disease specific 5- and 10-y-survival for the entire cohort was 61.0% and 57.9%, respectively. Multivariate analysis of the cohort identified tumor stage (HR 8.39, P <0.001 for distant disease), tumor type (signet ring HR 2.12, P = 0.025, and carcinoid HR = 0.14, P = 0.001), and surgical resection (no surgery HR 2.98, P = 0.010) as independent predictors of worse outcome. Conclusion: In the pediatric population, solid tumors of the colon and rectum occur more frequently in the right side of the colon in teenagers. Surgical resection significantly improves survival for most pediatric tumors of the lower gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalJournal of Surgical Research
Volume161
Issue number2
DOIs
StatePublished - Jun 15 2010
Externally publishedYes

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Rectum
Colon
Pediatrics
Neoplasms
Lower Gastrointestinal Tract
Carcinoid Tumor
Transverse Colon
Survival
Anal Canal
Histology
Epidemiology
Multivariate Analysis
Outcome Assessment (Health Care)
Databases
Incidence

Keywords

  • carcinoid
  • colon cancer
  • pediatrics

ASJC Scopus subject areas

  • Surgery

Cite this

Primary Solid Tumors of the Colon and Rectum in the Pediatric Patient : A Review of 270 Cases. / Yang, Relin; Cheung, Michael C.; Zhuge, Ying; Armstrong, Christopher; Koniaris, Leonidas; Sola, Juan E.

In: Journal of Surgical Research, Vol. 161, No. 2, 15.06.2010, p. 209-216.

Research output: Contribution to journalArticle

Yang, Relin ; Cheung, Michael C. ; Zhuge, Ying ; Armstrong, Christopher ; Koniaris, Leonidas ; Sola, Juan E. / Primary Solid Tumors of the Colon and Rectum in the Pediatric Patient : A Review of 270 Cases. In: Journal of Surgical Research. 2010 ; Vol. 161, No. 2. pp. 209-216.
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abstract = "Objective: To study the outcomes of solid tumors of the colon and rectum in pediatric patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1973-2005) was queried for patients less than 20 y of age. Results: Overall, 270 patients with malignant tumors of the lower gastrointestinal tract were identified. The annual incidence was 1.04 cases per million in 2005. Overall, equal distribution between boys (50.7{\%}) and girls (49.3{\%}) was observed. The majority of tumors arose in adolescents (68.1{\%} were older than 15 y). Tumors were more commonly seen in white (77.8{\%}) and non-Hispanic (78.9{\%}) patients. Tumors were identified in the right colon (45.9{\%}), transverse colon (9.3{\%}), left colon (20.4{\%}), rectum (15.2{\%}), and anal canal (1.1{\%}). The most common histology of these tumors was adenocarcinoma (35.6{\%}), followed by carcinoid (34.1{\%}). Disease specific 5- and 10-y-survival for the entire cohort was 61.0{\%} and 57.9{\%}, respectively. Multivariate analysis of the cohort identified tumor stage (HR 8.39, P <0.001 for distant disease), tumor type (signet ring HR 2.12, P = 0.025, and carcinoid HR = 0.14, P = 0.001), and surgical resection (no surgery HR 2.98, P = 0.010) as independent predictors of worse outcome. Conclusion: In the pediatric population, solid tumors of the colon and rectum occur more frequently in the right side of the colon in teenagers. Surgical resection significantly improves survival for most pediatric tumors of the lower gastrointestinal tract.",
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