1. 1. The complete amino acid sequences of carnine and feline amyloid A (AA) protein were determined and compared with the sequence of human AA protein. 2. 2. The dog and cat AA proteins were 84% homologous with human AA through residue 69. 3. 3. Between the residues which correspond to 69 and 70 in the human sequence, the dog and cat proteins had an insertion of eight amino acids after which homology with human AA resumed. 4. 4. While human AA commonly ends at position 76, the carboxyl termini of dog and cat AA proteins corresponded to position 86 in the sequence of the precursor protein-serum amyloid A. 5. 5. These results are particularly interesting with respect to evolution of the serum amyloid A gene family.
|Original language||English (US)|
|Number of pages||9|
|Journal||Comparative Biochemistry and Physiology -- Part B: Biochemistry and|
|State||Published - 1989|
ASJC Scopus subject areas
- Molecular Biology