Primary structures of dog and cat amyloid A proteins: comparison to human AA

Barbara Kluve-Beckerman, Francis E. Dwulet, Stephen P. DiBartonla, Merrill D. Benson

Research output: Contribution to journalArticle

24 Scopus citations


1. 1. The complete amino acid sequences of carnine and feline amyloid A (AA) protein were determined and compared with the sequence of human AA protein. 2. 2. The dog and cat AA proteins were 84% homologous with human AA through residue 69. 3. 3. Between the residues which correspond to 69 and 70 in the human sequence, the dog and cat proteins had an insertion of eight amino acids after which homology with human AA resumed. 4. 4. While human AA commonly ends at position 76, the carboxyl termini of dog and cat AA proteins corresponded to position 86 in the sequence of the precursor protein-serum amyloid A. 5. 5. These results are particularly interesting with respect to evolution of the serum amyloid A gene family.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Issue number1
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Primary structures of dog and cat amyloid A proteins: comparison to human AA'. Together they form a unique fingerprint.

  • Cite this