Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup

A study of 18 cases

Mousa A. Al-Abbadi, Eyas M. Hattab, Musleh S. Tarawneh, Samir S. Amr, Attilio Orazi, Thomas Ulbright

Research output: Contribution to journalArticle

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Abstract

The most common type of primary testicular lymphoma is diffuse large B-cell type, which has the potential for aggressive clinical behavior. Diffuse large B-cell lymphoma can be further subclassified into two major prognostic categories: germinal center B-cell-like and nongerminal center B-cell-like. Such distinction is made possible using the immunohistochemical expression of CD10, Bcl-6 and MUM1. The aim of this study was to stratify primary testicular lymphoma of the diffuse large B-cell type according to this scheme. Immunohistochemical stains for CD10, Bcl-6 and MUM1 were performed on 18 cases of primary testicular lymphoma of diffuse large B-cell type. Subclassification was carried out as previously described where CD10 and/or Bcl-6 positivity and negativity for MUM1 were considered indicative of germinal center B-cell-like type and the opposite expression as nongerminal center B-cell-like type. The proliferative activity was determined using immunostaining with the Ki-67 antibody. Of 18 cases, 16 (89%) were found to belong to the nongerminal center B-cell-like type. Two cases (11%) were classified as germinal center B-cell-like type; one had a CD10-positive, Bcl-6-positive and MUM1-negative profile, and the other was CD10 negative, Bcl-6 positive and MUM1 negative. The former occurred in a 38-year-old patient who was human immunodeficiency virus positive. All the cases expressed high proliferative activity (≥50% Ki-67 labeling). We conclude that most (89%) primary testicular lymphomas of the diffuse large B-cell type belong to the nongerminal center B-cell-like subgroup and have high proliferative activity.

Original languageEnglish
Pages (from-to)1521-1527
Number of pages7
JournalModern Pathology
Volume19
Issue number12
DOIs
StatePublished - Dec 15 2006

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Lymphoma, Large B-Cell, Diffuse
B-Lymphocytes
Germinal Center
Coloring Agents
HIV
Antibodies

Keywords

  • B-cell lymphoma
  • Diffuse large cell lymphoma
  • Immunophenotype
  • Primary testicular lymphoma
  • Subclassification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup : A study of 18 cases. / Al-Abbadi, Mousa A.; Hattab, Eyas M.; Tarawneh, Musleh S.; Amr, Samir S.; Orazi, Attilio; Ulbright, Thomas.

In: Modern Pathology, Vol. 19, No. 12, 15.12.2006, p. 1521-1527.

Research output: Contribution to journalArticle

Al-Abbadi, Mousa A. ; Hattab, Eyas M. ; Tarawneh, Musleh S. ; Amr, Samir S. ; Orazi, Attilio ; Ulbright, Thomas. / Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup : A study of 18 cases. In: Modern Pathology. 2006 ; Vol. 19, No. 12. pp. 1521-1527.
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abstract = "The most common type of primary testicular lymphoma is diffuse large B-cell type, which has the potential for aggressive clinical behavior. Diffuse large B-cell lymphoma can be further subclassified into two major prognostic categories: germinal center B-cell-like and nongerminal center B-cell-like. Such distinction is made possible using the immunohistochemical expression of CD10, Bcl-6 and MUM1. The aim of this study was to stratify primary testicular lymphoma of the diffuse large B-cell type according to this scheme. Immunohistochemical stains for CD10, Bcl-6 and MUM1 were performed on 18 cases of primary testicular lymphoma of diffuse large B-cell type. Subclassification was carried out as previously described where CD10 and/or Bcl-6 positivity and negativity for MUM1 were considered indicative of germinal center B-cell-like type and the opposite expression as nongerminal center B-cell-like type. The proliferative activity was determined using immunostaining with the Ki-67 antibody. Of 18 cases, 16 (89{\%}) were found to belong to the nongerminal center B-cell-like type. Two cases (11{\%}) were classified as germinal center B-cell-like type; one had a CD10-positive, Bcl-6-positive and MUM1-negative profile, and the other was CD10 negative, Bcl-6 positive and MUM1 negative. The former occurred in a 38-year-old patient who was human immunodeficiency virus positive. All the cases expressed high proliferative activity (≥50{\%} Ki-67 labeling). We conclude that most (89{\%}) primary testicular lymphomas of the diffuse large B-cell type belong to the nongerminal center B-cell-like subgroup and have high proliferative activity.",
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