Principles

Johannes G. Filser, Jeroen T.M. Buters, Leslie Schwarz, John B. Watkins, Lesley Stanley, Jens Schlossmann, Franz Hofmann, Victor J. Feron, Diana Jonker, Thomas Efferth, Bernd Kaina, Horst Spielmann, Peter Calow, Valery E. Forbes

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The object of toxicokinetics is the investigation of absorption, distribution, and elimination of toxicants and their toxicologically relevant metabolites as functions of dose and time.

Original languageEnglish (US)
Title of host publicationToxicology and Risk Assessment
Subtitle of host publicationA Comprehensive Introduction
PublisherJohn Wiley & Sons, Ltd
Pages19-203
Number of pages185
ISBN (Print)9780470868935
DOIs
StatePublished - Feb 8 2008

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Keywords

  • Anion-transport systems
  • Cancer-linked disease
  • Enzyme-mediated substance conversion
  • Intravascular thrombus formation
  • Isoenzymes exhibiting different substrate specificities
  • Messenger ribonucleic acid (mRNA)
  • Morphologically and functionally differing entities
  • One-compartment model saturation kinetics
  • Richly perfused organs
  • Toxic potential and (estimated) exposure

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Filser, J. G., Buters, J. T. M., Schwarz, L., Watkins, J. B., Stanley, L., Schlossmann, J., Hofmann, F., Feron, V. J., Jonker, D., Efferth, T., Kaina, B., Spielmann, H., Calow, P., & Forbes, V. E. (2008). Principles. In Toxicology and Risk Assessment: A Comprehensive Introduction (pp. 19-203). John Wiley & Sons, Ltd. https://doi.org/10.1002/9780470868959.ch2