Pro-opiomelanocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorder

Wade H. Berrettini, John Nurnberger, J. S D Chan, George P. Chrousos, Lazlo Gaspar, Philip W. Gold, N. G. Seidah, Susan Simmons-Alling, Lynn R. Goldin, Michel Chrétien, Elliot S. Gershon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Five peptide fragments of pro-opiomelanocortin (α-melanocyte-stimulating hormone, β-lipoprotin, adrenocorticotropic hormone, β-endorphin, and the N-terminal fragment of pro-opiomelanocortin) were measured by radioimmunoassay in cerebrospinal fluid (CSF) and plasma from 31 normal volunteers and 26 euthymic lithium-treated bipolar patients (14 of whom provided a second CSF sample in the unmedicated state). With the exception of α-melanocyte-stimulating hormone, in the normal volunteers' CSF, levels of these peptides were highly correlated with one another, suggesting that: (1) some common regulatory factor may control the levels of these four peptides in CSF; and (2) CSF α-melanocyte-stimulating hormone is independently regulated from the other pro-opiomelanocortin products. Some of these correlations were absent in the patient groups, suggesting subtle alterations in pro-opiomelanocortin processing in manic-depressive illness. No effect of lithium on the CSF levels of these peptides was observed. No group differences were found.

Original languageEnglish (US)
Pages (from-to)287-302
Number of pages16
JournalPsychiatry Research
Volume16
Issue number4
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Pro-Opiomelanocortin
Depressive Disorder
Bipolar Disorder
Cerebrospinal Fluid
Melanocyte-Stimulating Hormones
Peptides
Lithium
Healthy Volunteers
Endorphins
Peptide Fragments
Adrenocorticotropic Hormone
Radioimmunoassay

Keywords

  • Cerebrospinal fluid peptides
  • manic-depressive illness

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Berrettini, W. H., Nurnberger, J., Chan, J. S. D., Chrousos, G. P., Gaspar, L., Gold, P. W., ... Gershon, E. S. (1985). Pro-opiomelanocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorder. Psychiatry Research, 16(4), 287-302. https://doi.org/10.1016/0165-1781(85)90120-9

Pro-opiomelanocortin-related peptides in cerebrospinal fluid : A study of manic-depressive disorder. / Berrettini, Wade H.; Nurnberger, John; Chan, J. S D; Chrousos, George P.; Gaspar, Lazlo; Gold, Philip W.; Seidah, N. G.; Simmons-Alling, Susan; Goldin, Lynn R.; Chrétien, Michel; Gershon, Elliot S.

In: Psychiatry Research, Vol. 16, No. 4, 1985, p. 287-302.

Research output: Contribution to journalArticle

Berrettini, WH, Nurnberger, J, Chan, JSD, Chrousos, GP, Gaspar, L, Gold, PW, Seidah, NG, Simmons-Alling, S, Goldin, LR, Chrétien, M & Gershon, ES 1985, 'Pro-opiomelanocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorder', Psychiatry Research, vol. 16, no. 4, pp. 287-302. https://doi.org/10.1016/0165-1781(85)90120-9
Berrettini, Wade H. ; Nurnberger, John ; Chan, J. S D ; Chrousos, George P. ; Gaspar, Lazlo ; Gold, Philip W. ; Seidah, N. G. ; Simmons-Alling, Susan ; Goldin, Lynn R. ; Chrétien, Michel ; Gershon, Elliot S. / Pro-opiomelanocortin-related peptides in cerebrospinal fluid : A study of manic-depressive disorder. In: Psychiatry Research. 1985 ; Vol. 16, No. 4. pp. 287-302.
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