Pro-opiomelanocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorder

Wade H. Berrettini, John I. Nurnberger, J. S.D. Chan, George P. Chrousos, Lazlo Gaspar, Philip W. Gold, N. G. Seidah, Susan Simmons-Alling, Lynn R. Goldin, Michel Chrétien, Elliot S. Gershon

Research output: Contribution to journalArticle

17 Scopus citations


Five peptide fragments of pro-opiomelanocortin (α-melanocyte-stimulating hormone, β-lipoprotin, adrenocorticotropic hormone, β-endorphin, and the N-terminal fragment of pro-opiomelanocortin) were measured by radioimmunoassay in cerebrospinal fluid (CSF) and plasma from 31 normal volunteers and 26 euthymic lithium-treated bipolar patients (14 of whom provided a second CSF sample in the unmedicated state). With the exception of α-melanocyte-stimulating hormone, in the normal volunteers' CSF, levels of these peptides were highly correlated with one another, suggesting that: (1) some common regulatory factor may control the levels of these four peptides in CSF; and (2) CSF α-melanocyte-stimulating hormone is independently regulated from the other pro-opiomelanocortin products. Some of these correlations were absent in the patient groups, suggesting subtle alterations in pro-opiomelanocortin processing in manic-depressive illness. No effect of lithium on the CSF levels of these peptides was observed. No group differences were found.

Original languageEnglish (US)
Pages (from-to)287-302
Number of pages16
JournalPsychiatry Research
Issue number4
StatePublished - Dec 1985


  • Cerebrospinal fluid peptides
  • manic-depressive illness

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Berrettini, W. H., Nurnberger, J. I., Chan, J. S. D., Chrousos, G. P., Gaspar, L., Gold, P. W., Seidah, N. G., Simmons-Alling, S., Goldin, L. R., Chrétien, M., & Gershon, E. S. (1985). Pro-opiomelanocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorder. Psychiatry Research, 16(4), 287-302.