PRO Spective evaluation of chronic pancreatitis for epid emiologic and translational studies: Rationale and study design for PROCEED from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

Dhiraj Yadav, Walter G. Park, Evan L. Fogel, Liang Li, Suresh T. Chari, Ziding Feng, William E. Fisher, Christopher E. Forsmark, Christie Y. Jeon, Aida Habtezion, Phil A. Hart, Steven J. Hughes, Mohamed O. Othman, Jo Ann S. Rinaudo, Stephen J. Pandol, Temel Tirkes, Jose Serrano, Sudhir Srivastava, Stephen K. Van Den Eeden, David C. WhitcombMark Topazian, Darwin L. Conwell

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP. In addition to collecting detailed information using structured case report forms and protocol-mandated evaluations at baseline and during follow-up, PROCEED will establish a linked biorepository of blood, urine, saliva, stool, pancreatic fluid, and pancreatic tissue. Enrollment for PROCEED began in June 2017. As of July 1, 2018, nine clinical centers of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer are enrolling, and 350 subjects have completed baseline evaluation. In conclusion, PROCEED will provide the most accurate and reliable estimates to date on progression of CP. The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP.

Original languageEnglish (US)
Pages (from-to)1229-1238
Number of pages10
JournalPancreas
Volume47
Issue number10
DOIs
StatePublished - Nov 1 2018

Keywords

  • alcohol
  • biorepository
  • cohort
  • genetic
  • pancreas
  • tobacco

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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