Probing dry-weight improves left ventricular mass index

Rajiv Agarwal, J. Michael Bouldin, Robert P. Light, Ashok Garg

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Although probing dry-weight improves blood pressure control, its effect on echocardiographic left ventricular mass index (LVMI) is unknown. Methods: Shortly following dialysis, 292 echocardiograms in 150 patients participating in the DRIP trial were obtained at baseline and longitudinally every 4 weeks on 2 occasions. Results: At baseline, LVMI was 136.3 g/m 2 in the control group and 138.7 g/m2 in the ultrafiltration group (p > 0.2 for difference). The change from baseline in LVMI in the control group was +3.5 g/m2 at 4 weeks and +0.3 g/m 2 at 8 weeks (p > 0.2 for both changes). The change from baseline in LVMI in the ultrafiltration group was -7.4 g/m2 at 4 weeks (p = 0.005) and -6.3 g/m2 at 8 weeks (p = 0.045). With ultrafiltration, the change in LVMI diameter was -10.9 g/m2 more compared to the control group at 4 weeks (p = 0.012) and -6.6 g/m2 more compared to the control group at 8 weeks (p = 0.21). The reduction in interdialytic ambulatory blood pressure was also greater in response to probing dry-weight in those in the top half of LVMI at baseline (p = 0.02 for interaction effect at week 8). Conclusion: LVMI, an important determinant of prognosis among long-term dialysis patients, is responsive to probing dry-weight.

Original languageEnglish (US)
Pages (from-to)373-380
Number of pages8
JournalAmerican Journal of Nephrology
Volume33
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

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Ultrafiltration
Weights and Measures
Control Groups
Dialysis
Blood Pressure

Keywords

  • Ambulatory blood pressure
  • Echocardiogram
  • Hemodialysis
  • Hypertension
  • Left ventricular hypertrophy
  • Left ventricular systolic function
  • Ultrafiltration
  • Volume overload

ASJC Scopus subject areas

  • Nephrology

Cite this

Probing dry-weight improves left ventricular mass index. / Agarwal, Rajiv; Bouldin, J. Michael; Light, Robert P.; Garg, Ashok.

In: American Journal of Nephrology, Vol. 33, No. 4, 04.2011, p. 373-380.

Research output: Contribution to journalArticle

Agarwal, Rajiv ; Bouldin, J. Michael ; Light, Robert P. ; Garg, Ashok. / Probing dry-weight improves left ventricular mass index. In: American Journal of Nephrology. 2011 ; Vol. 33, No. 4. pp. 373-380.
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