Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review of Clinical Trials

Jun Liu, Guo bing Wan, Ming shi Huang, George Agyapong, Tian le Zou, Xue ying Zhang, Yen Wenn Liu, Yiqing Song, Ying Chieh Tsai, Xue jun Kong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD.

Original languageEnglish (US)
Pages (from-to)173-184
Number of pages12
JournalCurrent Medical Science
Volume39
Issue number2
DOIs
StatePublished - Apr 1 2019

Fingerprint

Behavioral Symptoms
Probiotics
Clinical Trials
Therapeutics
Comorbidity
Randomized Controlled Trials
Autism Spectrum Disorder

Keywords

  • autism spectrum disorder
  • probiotics
  • systematic review

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder : A Systematic Review of Clinical Trials. / Liu, Jun; Wan, Guo bing; Huang, Ming shi; Agyapong, George; Zou, Tian le; Zhang, Xue ying; Liu, Yen Wenn; Song, Yiqing; Tsai, Ying Chieh; Kong, Xue jun.

In: Current Medical Science, Vol. 39, No. 2, 01.04.2019, p. 173-184.

Research output: Contribution to journalArticle

Liu, Jun ; Wan, Guo bing ; Huang, Ming shi ; Agyapong, George ; Zou, Tian le ; Zhang, Xue ying ; Liu, Yen Wenn ; Song, Yiqing ; Tsai, Ying Chieh ; Kong, Xue jun. / Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder : A Systematic Review of Clinical Trials. In: Current Medical Science. 2019 ; Vol. 39, No. 2. pp. 173-184.
@article{0e3444428904495c9b861e3be570b267,
title = "Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review of Clinical Trials",
abstract = "The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD.",
keywords = "autism spectrum disorder, probiotics, systematic review",
author = "Jun Liu and Wan, {Guo bing} and Huang, {Ming shi} and George Agyapong and Zou, {Tian le} and Zhang, {Xue ying} and Liu, {Yen Wenn} and Yiqing Song and Tsai, {Ying Chieh} and Kong, {Xue jun}",
year = "2019",
month = "4",
day = "1",
doi = "10.1007/s11596-019-2016-4",
language = "English (US)",
volume = "39",
pages = "173--184",
journal = "Current Medical Science",
issn = "2096-5230",
publisher = "Huazhong University of Science and Technology",
number = "2",

}

TY - JOUR

T1 - Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder

T2 - A Systematic Review of Clinical Trials

AU - Liu, Jun

AU - Wan, Guo bing

AU - Huang, Ming shi

AU - Agyapong, George

AU - Zou, Tian le

AU - Zhang, Xue ying

AU - Liu, Yen Wenn

AU - Song, Yiqing

AU - Tsai, Ying Chieh

AU - Kong, Xue jun

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD.

AB - The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD.

KW - autism spectrum disorder

KW - probiotics

KW - systematic review

UR - http://www.scopus.com/inward/record.url?scp=85064936745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064936745&partnerID=8YFLogxK

U2 - 10.1007/s11596-019-2016-4

DO - 10.1007/s11596-019-2016-4

M3 - Article

C2 - 31016507

AN - SCOPUS:85064936745

VL - 39

SP - 173

EP - 184

JO - Current Medical Science

JF - Current Medical Science

SN - 2096-5230

IS - 2

ER -