Productive cross-talk with the microenvironment: A critical step in ovarian cancer metastasis

Mohamed A.Abd El Aziz, Komal Agarwal, Subramanyam Dasari, Anirban K. Mitra

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Most ovarian cancer patients present with disseminated disease at the time of their diagnosis, which is one of the main reasons for their poor prognosis. Metastasis is a multi-step process and a clear understanding of the mechanism of regulation of these steps remains elusive. Productive reciprocal interactions between the metastasizing ovarian cancer cells and the microenvironment of the metastatic site or the tumor microenvironment play an important role in the successful establishment of metastasis. Much progress has been made in the recent past in our understanding of such interactions and the role of the cellular and acellular components of the microenvironment in establishing the metastatic tumors. This review will outline the role of the microenvironmental components of the ovarian cancer metastatic niche and their role in helping establish the metastatic tumors. Special emphasis will be given to the mesothelial cells, which are the first cells encountered by the cancer cells at the site of metastasis.

Original languageEnglish (US)
Article number1608
Issue number10
StatePublished - Oct 2019


  • Adipocytes
  • Cross-talk
  • ECM
  • Fibroblasts
  • Mesothelial cells
  • Metastasis
  • Microenvironment
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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