Progenitor cells in the pulmonary circulation

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The mechanisms involved in the regulation of pulmonary vascular endothelial cells to replace aged or injured cells remains poorly understood, although differences in proliferative potential between the microvascular and macrovascular endothelium are well described. The presence of resident pulmonary vascular endothelial progenitor cells in rats and mice has been recently reported. These resident endothelial progenitor cells display clonal proliferative potential, restricted expression of cell surface molecules to those typical of lung endothelium, and in vivo vessel-forming ability upon transplantation into recipient animals. The rat pulmonary microvascular endothelium is enriched in resident progenitor cells, with the highest proliferative potentialcompared with the pulmonarymacrovascular endothelium. Preliminary evidence suggests that resident endothelial progenitor cells are present in the human lung vasculature, but whether differences in enrichment of the progenitors in various pulmonary vascular beds exist remains to be determined.

Original languageEnglish (US)
Pages (from-to)466-470
Number of pages5
JournalProceedings of the American Thoracic Society
Volume8
Issue number6
DOIs
StatePublished - Nov 1 2011

Keywords

  • Progenitor cells
  • Pulmonary circulation
  • Pulmonary vascular endothelial cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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