Progesterone alters biliary flow dynamics

Sean Tierney, Attila Nakeeb, Oliver Wong, Pamela A. Lipsett, Samuel Sostre, Henry A. Pitt, Keith D. Lillemoe

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: To test the hypothesis that progesterone alters sphincter of Oddi and gallbladder function and, therefore, bile flow dynamics. Summary Background Data: Although the effects of progesterone on the biliary tract have been implicated in the increased incidence of gallstones among women, the specific effects of prolonged elevation of progesterone levels, such as occurs with contraceptive progesterone implants and during pregnancy, on the sphincter of Oddi and biliary flow dynamics are still incompletely understood. Methods: Adult female prairie dogs were randomly assigned to receive subcutaneous implants containing either progesterone or inactive pellet matrix only. Hepatic bile partitioning and gallbladder emptying were determined 14 days later using 99mTc-Mebrofenin cholescintigraphy. Results: Significantly less hepatic bile partitioned into the gallbladder in progesterone-treated than in control animals. The gallbladder ejection fraction was significantly reduced from 73 ± 6% in controls to 59 ± 3% in the progesterone-treated animals. The rate of gallbladder emptying was significantly reduced from 3.6 ± 0.3%/minute to 2.9 ± 0.1%/minute. Conclusions: Progesterone administered as subcutaneous implants alters partitioning of hepatic bile between gallbladder and small intestine and, therefore, gallbladder filling. Progesterone also significantly impairs gallbladder emptying in response to cholecystokinin. The effects of progesterone on the sphincter of Oddi and the gallbladder may contribute to the greater prevalence of gallstones and biliary motility disorders among women.

Original languageEnglish (US)
Pages (from-to)205-209
Number of pages5
JournalAnnals of Surgery
Volume229
Issue number2
DOIs
StatePublished - Feb 1999
Externally publishedYes

Fingerprint

Progesterone
Gallbladder
Gallbladder Emptying
Sphincter of Oddi
Bile
Gallstones
Liver
Sciuridae
Cholecystokinin
Biliary Tract
Contraceptive Agents
Small Intestine
Pregnancy
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Tierney, S., Nakeeb, A., Wong, O., Lipsett, P. A., Sostre, S., Pitt, H. A., & Lillemoe, K. D. (1999). Progesterone alters biliary flow dynamics. Annals of Surgery, 229(2), 205-209. https://doi.org/10.1097/00000658-199902000-00007

Progesterone alters biliary flow dynamics. / Tierney, Sean; Nakeeb, Attila; Wong, Oliver; Lipsett, Pamela A.; Sostre, Samuel; Pitt, Henry A.; Lillemoe, Keith D.

In: Annals of Surgery, Vol. 229, No. 2, 02.1999, p. 205-209.

Research output: Contribution to journalArticle

Tierney, S, Nakeeb, A, Wong, O, Lipsett, PA, Sostre, S, Pitt, HA & Lillemoe, KD 1999, 'Progesterone alters biliary flow dynamics', Annals of Surgery, vol. 229, no. 2, pp. 205-209. https://doi.org/10.1097/00000658-199902000-00007
Tierney S, Nakeeb A, Wong O, Lipsett PA, Sostre S, Pitt HA et al. Progesterone alters biliary flow dynamics. Annals of Surgery. 1999 Feb;229(2):205-209. https://doi.org/10.1097/00000658-199902000-00007
Tierney, Sean ; Nakeeb, Attila ; Wong, Oliver ; Lipsett, Pamela A. ; Sostre, Samuel ; Pitt, Henry A. ; Lillemoe, Keith D. / Progesterone alters biliary flow dynamics. In: Annals of Surgery. 1999 ; Vol. 229, No. 2. pp. 205-209.
@article{257d10ed4cfd4c02968a913049242a64,
title = "Progesterone alters biliary flow dynamics",
abstract = "Objective: To test the hypothesis that progesterone alters sphincter of Oddi and gallbladder function and, therefore, bile flow dynamics. Summary Background Data: Although the effects of progesterone on the biliary tract have been implicated in the increased incidence of gallstones among women, the specific effects of prolonged elevation of progesterone levels, such as occurs with contraceptive progesterone implants and during pregnancy, on the sphincter of Oddi and biliary flow dynamics are still incompletely understood. Methods: Adult female prairie dogs were randomly assigned to receive subcutaneous implants containing either progesterone or inactive pellet matrix only. Hepatic bile partitioning and gallbladder emptying were determined 14 days later using 99mTc-Mebrofenin cholescintigraphy. Results: Significantly less hepatic bile partitioned into the gallbladder in progesterone-treated than in control animals. The gallbladder ejection fraction was significantly reduced from 73 ± 6{\%} in controls to 59 ± 3{\%} in the progesterone-treated animals. The rate of gallbladder emptying was significantly reduced from 3.6 ± 0.3{\%}/minute to 2.9 ± 0.1{\%}/minute. Conclusions: Progesterone administered as subcutaneous implants alters partitioning of hepatic bile between gallbladder and small intestine and, therefore, gallbladder filling. Progesterone also significantly impairs gallbladder emptying in response to cholecystokinin. The effects of progesterone on the sphincter of Oddi and the gallbladder may contribute to the greater prevalence of gallstones and biliary motility disorders among women.",
author = "Sean Tierney and Attila Nakeeb and Oliver Wong and Lipsett, {Pamela A.} and Samuel Sostre and Pitt, {Henry A.} and Lillemoe, {Keith D.}",
year = "1999",
month = "2",
doi = "10.1097/00000658-199902000-00007",
language = "English (US)",
volume = "229",
pages = "205--209",
journal = "Annals of Surgery",
issn = "0003-4932",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Progesterone alters biliary flow dynamics

AU - Tierney, Sean

AU - Nakeeb, Attila

AU - Wong, Oliver

AU - Lipsett, Pamela A.

AU - Sostre, Samuel

AU - Pitt, Henry A.

AU - Lillemoe, Keith D.

PY - 1999/2

Y1 - 1999/2

N2 - Objective: To test the hypothesis that progesterone alters sphincter of Oddi and gallbladder function and, therefore, bile flow dynamics. Summary Background Data: Although the effects of progesterone on the biliary tract have been implicated in the increased incidence of gallstones among women, the specific effects of prolonged elevation of progesterone levels, such as occurs with contraceptive progesterone implants and during pregnancy, on the sphincter of Oddi and biliary flow dynamics are still incompletely understood. Methods: Adult female prairie dogs were randomly assigned to receive subcutaneous implants containing either progesterone or inactive pellet matrix only. Hepatic bile partitioning and gallbladder emptying were determined 14 days later using 99mTc-Mebrofenin cholescintigraphy. Results: Significantly less hepatic bile partitioned into the gallbladder in progesterone-treated than in control animals. The gallbladder ejection fraction was significantly reduced from 73 ± 6% in controls to 59 ± 3% in the progesterone-treated animals. The rate of gallbladder emptying was significantly reduced from 3.6 ± 0.3%/minute to 2.9 ± 0.1%/minute. Conclusions: Progesterone administered as subcutaneous implants alters partitioning of hepatic bile between gallbladder and small intestine and, therefore, gallbladder filling. Progesterone also significantly impairs gallbladder emptying in response to cholecystokinin. The effects of progesterone on the sphincter of Oddi and the gallbladder may contribute to the greater prevalence of gallstones and biliary motility disorders among women.

AB - Objective: To test the hypothesis that progesterone alters sphincter of Oddi and gallbladder function and, therefore, bile flow dynamics. Summary Background Data: Although the effects of progesterone on the biliary tract have been implicated in the increased incidence of gallstones among women, the specific effects of prolonged elevation of progesterone levels, such as occurs with contraceptive progesterone implants and during pregnancy, on the sphincter of Oddi and biliary flow dynamics are still incompletely understood. Methods: Adult female prairie dogs were randomly assigned to receive subcutaneous implants containing either progesterone or inactive pellet matrix only. Hepatic bile partitioning and gallbladder emptying were determined 14 days later using 99mTc-Mebrofenin cholescintigraphy. Results: Significantly less hepatic bile partitioned into the gallbladder in progesterone-treated than in control animals. The gallbladder ejection fraction was significantly reduced from 73 ± 6% in controls to 59 ± 3% in the progesterone-treated animals. The rate of gallbladder emptying was significantly reduced from 3.6 ± 0.3%/minute to 2.9 ± 0.1%/minute. Conclusions: Progesterone administered as subcutaneous implants alters partitioning of hepatic bile between gallbladder and small intestine and, therefore, gallbladder filling. Progesterone also significantly impairs gallbladder emptying in response to cholecystokinin. The effects of progesterone on the sphincter of Oddi and the gallbladder may contribute to the greater prevalence of gallstones and biliary motility disorders among women.

UR - http://www.scopus.com/inward/record.url?scp=0033504889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033504889&partnerID=8YFLogxK

U2 - 10.1097/00000658-199902000-00007

DO - 10.1097/00000658-199902000-00007

M3 - Article

VL - 229

SP - 205

EP - 209

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 2

ER -