Prognosis of patients who relapse after fertility-sparing surgery in epithelial ovarian cancer

Olivier Marpeau, Jeanne Schilder, Yaelle Zafrani, Catherine Uzan, Sebastien Gouy, Catherine Lhommé, Philippe Morice

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: The prognosis for patients who develop a recurrence after fertility-sparing surgery for epithelial ovarian cancer (EOC) remains unclear. This is the first study to evaluate survival in patients who have developed a recurrence in this context. Methods: The outcomes of relapsed patients reported in the literature in the four main series of fertility-sparing surgery for EOC were reviewed and updated (where feasible). Results: Twenty-three of the 166 patients in the series were reported to have recurrent disease. The site of the recurrence was the peritoneum (+/- remaining ovary) in 17 patients, and distant in six patients. Twelve patients died of recurrent disease, two are still alive with persistent disease, eight are disease-free, and one is alive but her exact status is not known. Among eight patients (34%) with an isolated recurrence on the remaining ovary, two died and one was lost to follow-up. Conclusion:In this carefully monitored population, including systematic radiological examinations, the rate of isolated recurrences on the spared ovary is low. Recurrence in these patients carries a poor prognosis. Such results suggest that initial selection of candidates for fertility-sparing surgery should be carefully defined to reduce the rate of recurrences that carry a poor prognosis.

Original languageEnglish
Pages (from-to)478-483
Number of pages6
JournalAnnals of Surgical Oncology
Volume15
Issue number2
DOIs
StatePublished - Feb 2008

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Fertility
Recurrence
Ovary
Ovarian epithelial cancer
Peritoneum
Lost to Follow-Up
Survival
Population

Keywords

  • Conservative surgery
  • Outcomes
  • Ovarian cancer
  • Prognosis
  • Recurrence

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Prognosis of patients who relapse after fertility-sparing surgery in epithelial ovarian cancer. / Marpeau, Olivier; Schilder, Jeanne; Zafrani, Yaelle; Uzan, Catherine; Gouy, Sebastien; Lhommé, Catherine; Morice, Philippe.

In: Annals of Surgical Oncology, Vol. 15, No. 2, 02.2008, p. 478-483.

Research output: Contribution to journalArticle

Marpeau, Olivier ; Schilder, Jeanne ; Zafrani, Yaelle ; Uzan, Catherine ; Gouy, Sebastien ; Lhommé, Catherine ; Morice, Philippe. / Prognosis of patients who relapse after fertility-sparing surgery in epithelial ovarian cancer. In: Annals of Surgical Oncology. 2008 ; Vol. 15, No. 2. pp. 478-483.
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