Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms

Thomas J. Montine, Jacob J. Vandersteenhoven, Alasandra Aguzzi, Orest Boyko, Richard K. Dodge, Billie Jo Kerns, Peter C. Burger

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114 Citations (Scopus)

Abstract

HISTOLOGICAL GRADING OF fibrillary astrocytic neoplasms has proved to be a valuable prognostic tool, but potentially could benefit from more objective data, such as estimates of proliferative rate. The authors have investigated the prognostic utility of quantitative Ki-67 immunoreactivity in a prospective survival analysis of 36 adult patients with astrocytoma, anaplastic astrocytoma, or glioblastoma multiforme diagnosed between 1987 and 1992. A digital image analyzer was used to assay proliferation indices (PIs) in surgical biopsy specimens obtained at first diagnosis (32 of 36) or at a second biopsy of histologically unchanged high-grade disease (4 of 36). A Ki-67 PI of ≥7.5% was associated with higher histological grade and poorer survival, and the Ki-67 PI was more significantly related to survival (P < 0.001) than histological grade as determined by a modified Ringertz grading system (P = 0.002). Survival analysis within histological grades suggested that astrocytoma patients with PI ≥ 3% may be at increased risk for shorter survival than those with PI < 3%.

Original languageEnglish (US)
Pages (from-to)674-679
Number of pages6
JournalNeurosurgery
Volume34
Issue number4
StatePublished - 1994
Externally publishedYes

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Astrocytoma
Survival Analysis
Survival
Biopsy
Neoplasms
Glioblastoma

Keywords

  • Astrocytoma
  • Prognosis
  • Proliferation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Montine, T. J., Vandersteenhoven, J. J., Aguzzi, A., Boyko, O., Dodge, R. K., Kerns, B. J., & Burger, P. C. (1994). Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms. Neurosurgery, 34(4), 674-679.

Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms. / Montine, Thomas J.; Vandersteenhoven, Jacob J.; Aguzzi, Alasandra; Boyko, Orest; Dodge, Richard K.; Kerns, Billie Jo; Burger, Peter C.

In: Neurosurgery, Vol. 34, No. 4, 1994, p. 674-679.

Research output: Contribution to journalArticle

Montine, TJ, Vandersteenhoven, JJ, Aguzzi, A, Boyko, O, Dodge, RK, Kerns, BJ & Burger, PC 1994, 'Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms', Neurosurgery, vol. 34, no. 4, pp. 674-679.
Montine TJ, Vandersteenhoven JJ, Aguzzi A, Boyko O, Dodge RK, Kerns BJ et al. Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms. Neurosurgery. 1994;34(4):674-679.
Montine, Thomas J. ; Vandersteenhoven, Jacob J. ; Aguzzi, Alasandra ; Boyko, Orest ; Dodge, Richard K. ; Kerns, Billie Jo ; Burger, Peter C. / Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms. In: Neurosurgery. 1994 ; Vol. 34, No. 4. pp. 674-679.
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