Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms

Thomas J. Montine, Jacob J. Vandersteenhoven, Alasandra Aguzzi, Orst B. Boyko, Richard K. Dodge, Billie Jo Kerns, Peter C. Burger

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

HISTOLOGICAL GRADING OF fibrillary astrocytic neoplasms has proved to be a valuable prognostic tool, but potentially could benefit from more objective data, such as estimates of proliferative rate. The authors have investigated the prognostic utility of quantitative Ki-67 immunoreactivity in a prospective survival analysis of 36 adult patients with astrocytoma, anaplastic astrocytoma, or glioblastoma multiforme diagnosed between 1987 and 1992. A digital image analyzer was used to assay proliferation indices (PIs) in surgical biopsy specimens obtained at first diagnosis (32 of 36) or at a second biopsy of histologically unchanged high-grade disease (4 of 36). A Ki-67 PI of ≥7.5% was associated with higher histological grade and poorer survival, and the Ki-67 PI was more significantly related to survival (P < 0.001) than histological grade as determined by a modified Ringertz grading system (P = 0.002). Survival analysis within histological grades suggested that astrocytoma patients with PI ≥ 3% may be at increased risk for shorter survival than those with PI < 3%.

Original languageEnglish (US)
Pages (from-to)674-679
Number of pages6
JournalNeurosurgery
Volume34
Issue number4
DOIs
StatePublished - Apr 1994

Keywords

  • Astrocytoma
  • Prognosis
  • Proliferation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms'. Together they form a unique fingerprint.

  • Cite this

    Montine, T. J., Vandersteenhoven, J. J., Aguzzi, A., Boyko, O. B., Dodge, R. K., Kerns, B. J., & Burger, P. C. (1994). Prognostic significance of ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms. Neurosurgery, 34(4), 674-679. https://doi.org/10.1227/00006123-199404000-00016