Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation

Michael A. Puskarich, Stephen Trzeciak, Nathan I. Shapiro, Ryan C. Arnold, Alan C. Heffner, Jeffrey Kline, Alan E. Jones

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objectives: Lactate clearance (LC) and central venous oxygen saturation (ScvO2) have been proposed as goals of early sepsis resuscitation. The authors sought to determine the agreement and prognostic value of achieving ScvO2 or LC goals in septic shock patients undergoing emergency department (ED)-based early resuscitation. Methods: This was a preplanned analysis of a multicenter ED randomized controlled trial of early sepsis resuscitation targeting three variables: central venous pressure, mean arterial pressure, and either ScvO2 or LC. Inclusion criteria included suspected infection, two or more systemic inflammation criteria, and either systolic blood pressure of 4 mmol/L. Both ScvO2 and LC were measured simultaneously. The ScvO2 goal was defined as ≥70%. Lactate was measured at enrollment and every 2 hours until the goal was reached or up to 6 hours. LC goal was defined as a decrease of ≥10% from initial measurement. The primary outcome was in-hospital mortality. Results: A total of 203 subjects were included, with an overall mortality of 19.7%. Achievement of the ScvO 2 goal only was associated with a mortality rate of 41% (9/22), while achievement of the LC goal only was associated with a mortality rate of 8% (2/25; proportion difference = 33%; 95% confidence interval [CI] = 9% to 55%). No agreement was found between goal achievement (κ = -0.02), and exact test for matched pairs demonstrated no significant difference between discordant pairs (p = 0.78). Conclusions: No agreement was found between LC and ScvO 2 goal achievement in early sepsis resuscitation. Achievement of a ScvO2≥ 70% without LC ≥ 10% was more strongly associated with mortality than achievement of LC ≥ 10% with failure to achieve ScvO 2≥ 70%.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalAcademic Emergency Medicine
Volume19
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

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Resuscitation
Lactic Acid
Sepsis
Oxygen
Mortality
Hospital Emergency Service
Blood Pressure
Central Venous Pressure
Septic Shock
Hospital Mortality
Arterial Pressure
Randomized Controlled Trials
Confidence Intervals
Inflammation
Infection

ASJC Scopus subject areas

  • Emergency Medicine

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Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. / Puskarich, Michael A.; Trzeciak, Stephen; Shapiro, Nathan I.; Arnold, Ryan C.; Heffner, Alan C.; Kline, Jeffrey; Jones, Alan E.

In: Academic Emergency Medicine, Vol. 19, No. 3, 03.2012, p. 252-258.

Research output: Contribution to journalArticle

Puskarich, Michael A. ; Trzeciak, Stephen ; Shapiro, Nathan I. ; Arnold, Ryan C. ; Heffner, Alan C. ; Kline, Jeffrey ; Jones, Alan E. / Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. In: Academic Emergency Medicine. 2012 ; Vol. 19, No. 3. pp. 252-258.
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abstract = "Objectives: Lactate clearance (LC) and central venous oxygen saturation (ScvO2) have been proposed as goals of early sepsis resuscitation. The authors sought to determine the agreement and prognostic value of achieving ScvO2 or LC goals in septic shock patients undergoing emergency department (ED)-based early resuscitation. Methods: This was a preplanned analysis of a multicenter ED randomized controlled trial of early sepsis resuscitation targeting three variables: central venous pressure, mean arterial pressure, and either ScvO2 or LC. Inclusion criteria included suspected infection, two or more systemic inflammation criteria, and either systolic blood pressure of 4 mmol/L. Both ScvO2 and LC were measured simultaneously. The ScvO2 goal was defined as ≥70{\%}. Lactate was measured at enrollment and every 2 hours until the goal was reached or up to 6 hours. LC goal was defined as a decrease of ≥10{\%} from initial measurement. The primary outcome was in-hospital mortality. Results: A total of 203 subjects were included, with an overall mortality of 19.7{\%}. Achievement of the ScvO 2 goal only was associated with a mortality rate of 41{\%} (9/22), while achievement of the LC goal only was associated with a mortality rate of 8{\%} (2/25; proportion difference = 33{\%}; 95{\%} confidence interval [CI] = 9{\%} to 55{\%}). No agreement was found between goal achievement (κ = -0.02), and exact test for matched pairs demonstrated no significant difference between discordant pairs (p = 0.78). Conclusions: No agreement was found between LC and ScvO 2 goal achievement in early sepsis resuscitation. Achievement of a ScvO2≥ 70{\%} without LC ≥ 10{\%} was more strongly associated with mortality than achievement of LC ≥ 10{\%} with failure to achieve ScvO 2≥ 70{\%}.",
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AB - Objectives: Lactate clearance (LC) and central venous oxygen saturation (ScvO2) have been proposed as goals of early sepsis resuscitation. The authors sought to determine the agreement and prognostic value of achieving ScvO2 or LC goals in septic shock patients undergoing emergency department (ED)-based early resuscitation. Methods: This was a preplanned analysis of a multicenter ED randomized controlled trial of early sepsis resuscitation targeting three variables: central venous pressure, mean arterial pressure, and either ScvO2 or LC. Inclusion criteria included suspected infection, two or more systemic inflammation criteria, and either systolic blood pressure of 4 mmol/L. Both ScvO2 and LC were measured simultaneously. The ScvO2 goal was defined as ≥70%. Lactate was measured at enrollment and every 2 hours until the goal was reached or up to 6 hours. LC goal was defined as a decrease of ≥10% from initial measurement. The primary outcome was in-hospital mortality. Results: A total of 203 subjects were included, with an overall mortality of 19.7%. Achievement of the ScvO 2 goal only was associated with a mortality rate of 41% (9/22), while achievement of the LC goal only was associated with a mortality rate of 8% (2/25; proportion difference = 33%; 95% confidence interval [CI] = 9% to 55%). No agreement was found between goal achievement (κ = -0.02), and exact test for matched pairs demonstrated no significant difference between discordant pairs (p = 0.78). Conclusions: No agreement was found between LC and ScvO 2 goal achievement in early sepsis resuscitation. Achievement of a ScvO2≥ 70% without LC ≥ 10% was more strongly associated with mortality than achievement of LC ≥ 10% with failure to achieve ScvO 2≥ 70%.

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