Prognostic value of circadian blood pressure variation in chronic kidney disease

Rajiv Agarwal, Shathabish S. Kariyanna, Robert P. Light

Research output: Contribution to journalArticle

17 Scopus citations


Background: Reduced circadian variation in blood pressure (BP) has been associated with cardiovascular morbidity, mortality and accelerated progression of kidney disease, but its independent prognostic value remains unknown. Methods: Using 2 definitions, one based on dipping and the other based on BP pattern (assessed by cosinor rhythmometry), we studied the prognosis of circadian BP variation among 322 patients, 179 (56%) of whom had chronic kidney disease (CKD). Results: During a follow-up period extending for up to 8.7 years, 116 (36%) patients died and 57 (32%) patients with CKD developed end-stage renal disease (ESRD). Compared to 106 patients (33%) who were dippers, the unadjusted hazard ratio (HR) for death among non-dippers was 2.03 (95% CI 1.30-3.16, p = 0.002). However, this HR became nonsignificant [1.39 (95% CI 0.89-2.19), p = 0.15] when adjusted for age and 24-hour average systolic BP. Although non-dipping was marginally associated with ESRD [HR 1.98 (95% CI 0.996-3.92), p = 0.051], even this association was weakened when adjusted for overall 24-hour systolic BP (HR 1.67, p = 0.15). Similar to the dipping definition, the BP pattern-based definition was significantly associated with mortality (p = 0.005) but not with ESRD (p = 0.68). Compared to those 'in-phase,' the HR for death among those 'out-of-phase' was 1.86 (95% CI 1.25-2.75, p = 0.002). Although this HR when adjusted for overall mean BP remained significant, when further adjusted for age, it too became nonsignificant. Conclusion: Among elderly veterans with or without CKD, circadian variation in BP is associated with mortality, but not ESRD. However, after accounting for common clinical risk factors, this association of circadian BP variation with mortality or ESRD is abolished.

Original languageEnglish (US)
Pages (from-to)547-553
Number of pages7
JournalAmerican journal of nephrology
Issue number6
StatePublished - Dec 1 2009
Externally publishedYes


  • Ambulatory blood pressure monitoring
  • Chronic kidney disease
  • Hypertension
  • Prognosis

ASJC Scopus subject areas

  • Nephrology

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