Abstract
In patients with temporal lobe epilepsy (TLE), high-resolution, magnetic resonance imaging (MRI) frequently demonstrates hippocampal atrophy and increased hippocampal signal. To assess the prognostic value of these findings, we studied 51 patients evaluated prospectively by a radiologist blinded to other preoperative evaluations. Thirty-one of 51 (61%) patients undergoing temporal lobectomy had visually apparent hippocampal atrophy or increased hippocampal signal on MRI (25 ipsilateral 3 contralateral, and 3 bilateral to the operated site). Patients with ipsilateral abnormalities became seizure-free more frequently than patients with normal scans [24 of 25 (96%) vs. 10 of 20 (50%) p <0.015]. Both ipsilateral hippocampal atrophy and ipsilateral increased hippocampal signal independently predicted a seizure- free outcome. Qualitative MRI provides important prognostic information in patients undergoing temporal lobectomy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 520-524 |
| Number of pages | 5 |
| Journal | Epilepsia |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- Epilepsy
- Magnetic resonance imaging
- Neurosurgery
- Seizure
- Temporal lobectomy
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients undergoing temporal lobectomy for medically refractory seizures. / Garcia, P. A.; Laxer, K. D.; Barbaro, Nicholas; Dillon, W. P.
In: Epilepsia, Vol. 35, No. 3, 1994, p. 520-524.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients undergoing temporal lobectomy for medically refractory seizures
AU - Garcia, P. A.
AU - Laxer, K. D.
AU - Barbaro, Nicholas
AU - Dillon, W. P.
PY - 1994
Y1 - 1994
N2 - In patients with temporal lobe epilepsy (TLE), high-resolution, magnetic resonance imaging (MRI) frequently demonstrates hippocampal atrophy and increased hippocampal signal. To assess the prognostic value of these findings, we studied 51 patients evaluated prospectively by a radiologist blinded to other preoperative evaluations. Thirty-one of 51 (61%) patients undergoing temporal lobectomy had visually apparent hippocampal atrophy or increased hippocampal signal on MRI (25 ipsilateral 3 contralateral, and 3 bilateral to the operated site). Patients with ipsilateral abnormalities became seizure-free more frequently than patients with normal scans [24 of 25 (96%) vs. 10 of 20 (50%) p <0.015]. Both ipsilateral hippocampal atrophy and ipsilateral increased hippocampal signal independently predicted a seizure- free outcome. Qualitative MRI provides important prognostic information in patients undergoing temporal lobectomy.
AB - In patients with temporal lobe epilepsy (TLE), high-resolution, magnetic resonance imaging (MRI) frequently demonstrates hippocampal atrophy and increased hippocampal signal. To assess the prognostic value of these findings, we studied 51 patients evaluated prospectively by a radiologist blinded to other preoperative evaluations. Thirty-one of 51 (61%) patients undergoing temporal lobectomy had visually apparent hippocampal atrophy or increased hippocampal signal on MRI (25 ipsilateral 3 contralateral, and 3 bilateral to the operated site). Patients with ipsilateral abnormalities became seizure-free more frequently than patients with normal scans [24 of 25 (96%) vs. 10 of 20 (50%) p <0.015]. Both ipsilateral hippocampal atrophy and ipsilateral increased hippocampal signal independently predicted a seizure- free outcome. Qualitative MRI provides important prognostic information in patients undergoing temporal lobectomy.
KW - Epilepsy
KW - Magnetic resonance imaging
KW - Neurosurgery
KW - Seizure
KW - Temporal lobectomy
UR - http://www.scopus.com/inward/record.url?scp=0028284712&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028284712&partnerID=8YFLogxK
U2 - 10.1111/j.1528-1157.1994.tb02471.x
DO - 10.1111/j.1528-1157.1994.tb02471.x
M3 - Article
C2 - 8026397
AN - SCOPUS:0028284712
VL - 35
SP - 520
EP - 524
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 3
ER -