Prognostic Value of Qualitative Magnetic Resonance Imaging Hippocampal Abnormalities in Patients Undergoing Temporal Lobectomy for Medically Refractory Seizures

Paul A. Garcia, Kenneth D. Laxer, Nicholas M. Barbaro, William P. Dillon

Research output: Contribution to journalArticle

114 Scopus citations


Summary: In patients with temporal lobe epilepsy (TLE), high‐resolution, magnetic resonance imaging (MRI) frequently demonstrates hippocampal atrophy and increased hippocampal signal. To assess the prognostic value of these findings, we studied 51 patients evaluated prospectively by a radiologist blinded to other preoperative evaluations. Thirty‐one of 51 (61%) patients undergoing temporal lobectomy had visually apparent hippocampal atrophy o r increased hippocampal signal on MRI (25 ipsilateral 3 contralateral, and bilateral to the operated site). Patients with ipsilateral abnormalities became seizure‐free more frequently than patients with normal scans [24 of 25 (96%) vs. 10 of 20 (50%) p < 0.015]. Both ipsilateral hippocampal atrophy and ipsilateral increased hippocampal signal independently predicted a seizure‐free outcome. Qualitative MRI provides important prognostic information in patients undergoing temporal lobectomy.

Original languageEnglish (US)
Pages (from-to)520-524
Number of pages5
Issue number3
StatePublished - May 1994



  • Epilepsy
  • Magnetic resonance imaging
  • Neurosurgery
  • Temporal lobectomy
  • eizure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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