Progression after AKI: UnderstanDing maladaptive repair processes to predict and identify therapeutic treatments

David P. Basile, Joseph V. Bonventre, Ravindra Mehta, Masaomi Nangaku, Robert Unwin, Mitchell H. Rosner, John A. Kellum, Claudio Ronco

Research output: Contribution to journalArticle

156 Scopus citations

Abstract

Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarDing the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury convened in April of 2014 and assigned aworking group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, incluDing an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.

Original languageEnglish (US)
Pages (from-to)687-697
Number of pages11
JournalJournal of the American Society of Nephrology
Volume27
Issue number3
DOIs
StatePublished - Mar 2016

ASJC Scopus subject areas

  • Nephrology

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