Progression of toxic epidermal necrolysis after tanning bed exposure

Na Tosha Gatson, Jared B. Travers, Mohammed Al-Hassani, Simon Warren, Ann Marie Hyatt, Jeffrey Travers

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: In addition to recreational tanning bed use, UV radiation exposures are sometimes sought to self-treat skin conditions. The ability of tanning bed radiation exposure to trigger toxic epidermal necrolysis has not been reported. Observations: A young woman attempted to treat a self-limiting drug hypersensitivity reaction via tanning bed radiation exposure, which resulted in a systemic toxic epidermal necrolysis-like reaction. Studies with cultured keratinocytes and an epithelial cell line reveal that UV-A radiation can synergize with other stimuli such as phorbol esters or interleukin 1 to produce large amounts of tumor necrosis factor, providing a potential mechanism for this exaggerated reaction. Conclusion: In addition to inducing photodamage and skin cancer, tanning bed radiation exposure can trigger a toxic epidermal necrolysis-like reaction, possibly via the exaggerated production of keratinocyte cytokines such as tumor necrosis factor.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalArchives of Dermatology
Volume147
Issue number6
DOIs
StatePublished - Jun 2011

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Tanning
Stevens-Johnson Syndrome
Keratinocytes
Tumor Necrosis Factor-alpha
Drug Hypersensitivity
Phorbol Esters
Skin Neoplasms
Interleukin-1
Epithelial Cells
Radiation
Cytokines
Cell Line
Skin
Radiation Exposure

ASJC Scopus subject areas

  • Dermatology

Cite this

Progression of toxic epidermal necrolysis after tanning bed exposure. / Gatson, Na Tosha; Travers, Jared B.; Al-Hassani, Mohammed; Warren, Simon; Hyatt, Ann Marie; Travers, Jeffrey.

In: Archives of Dermatology, Vol. 147, No. 6, 06.2011, p. 719-723.

Research output: Contribution to journalArticle

Gatson, Na Tosha ; Travers, Jared B. ; Al-Hassani, Mohammed ; Warren, Simon ; Hyatt, Ann Marie ; Travers, Jeffrey. / Progression of toxic epidermal necrolysis after tanning bed exposure. In: Archives of Dermatology. 2011 ; Vol. 147, No. 6. pp. 719-723.
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