Proinflammatory stem cell signaling in cardiac ischemia

Jeremy L. Herrmann, Troy A. Markel, Aaron M. Abarbanell, Brent R. Weil, Meijing Wang, Yue Wang, Jiangning Tan, Daniel R. Meldrum

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cardiovascular disease remains a leading cause of mortality in developed nations, despite continued advancement in modern therapy. Progenitor and stem cell-based therapy is a novel treatment for cardiovascular disease, and modest benefits in cardiac recovery have been achieved in small clinical trials. This therapeutic modality remains challenged by limitations of low donor-cell survival rates, transient recovery of cardiac function, and the technical difficulty of applying directed cell therapy. Understanding the signaling mechanisms involved in the stem cell response to ischemia has revealed opportunities to modify directly aspects of these pathways to improve their cardioprotective abilities. This review highlights general considerations of stem cell therapy for cardiac disease, reviews the major proinflammatory signaling pathways of mesenchymal stem cells, and reviews ex vivo modifications of stem cells based on these pathways. Antioxid.

Original languageEnglish
Pages (from-to)1883-1896
Number of pages14
JournalAntioxidants and Redox Signaling
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2009

Fingerprint

Cell signaling
Stem cells
Stem Cells
Ischemia
Cell- and Tissue-Based Therapy
Cardiovascular Diseases
Recovery
Recovery of Function
Mesenchymal Stromal Cells
Developed Countries
Heart Diseases
Cell Survival
Therapeutics
Survival Rate
Cells
Clinical Trials
Mortality

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Herrmann, J. L., Markel, T. A., Abarbanell, A. M., Weil, B. R., Wang, M., Wang, Y., ... Meldrum, D. R. (2009). Proinflammatory stem cell signaling in cardiac ischemia. Antioxidants and Redox Signaling, 11(8), 1883-1896. https://doi.org/10.1089/ars.2009.2434

Proinflammatory stem cell signaling in cardiac ischemia. / Herrmann, Jeremy L.; Markel, Troy A.; Abarbanell, Aaron M.; Weil, Brent R.; Wang, Meijing; Wang, Yue; Tan, Jiangning; Meldrum, Daniel R.

In: Antioxidants and Redox Signaling, Vol. 11, No. 8, 01.08.2009, p. 1883-1896.

Research output: Contribution to journalArticle

Herrmann, JL, Markel, TA, Abarbanell, AM, Weil, BR, Wang, M, Wang, Y, Tan, J & Meldrum, DR 2009, 'Proinflammatory stem cell signaling in cardiac ischemia', Antioxidants and Redox Signaling, vol. 11, no. 8, pp. 1883-1896. https://doi.org/10.1089/ars.2009.2434
Herrmann, Jeremy L. ; Markel, Troy A. ; Abarbanell, Aaron M. ; Weil, Brent R. ; Wang, Meijing ; Wang, Yue ; Tan, Jiangning ; Meldrum, Daniel R. / Proinflammatory stem cell signaling in cardiac ischemia. In: Antioxidants and Redox Signaling. 2009 ; Vol. 11, No. 8. pp. 1883-1896.
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