Prolactin induced stimulation of rat renal adenylate cyclase and autoradiographic localization to the distal nephron

A. P. Evan, G. C. Palmer, M. S. Lucci, S. Solomon

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Prolactin was shown to activate adenylate cyclase in broken cellular enzyme preparations from rat renal medulla. Likewise, vasopressin was effective on this enzyme system. Parathyroid hormone was similarly active in the renal cortex. The simultaneous administration of vasopressin and prolactin to medullary kidney slices did not result in an additive effect in stimulating medullary adenyl cyclase. Audioradiographic techniques revealed a selective and prolonged localization of intravenously injected 125I-prolactin to the thick limb of the loop of Henle, the distal tubule and the collecting duct. It is concluded that prolactin activates medullary adenylate cyclase, and may do so by occupying ADH receptors.

Original languageEnglish (US)
Pages (from-to)266-276
Number of pages11
JournalNephron
Volume18
Issue number5
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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