Prolactin synthesis in cultured pituitary cells is chloride-dependent

Richard Day, P. M. Hinkle

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Release of prolactin from both normal pituitary cells and rat pituitary tumor (GH) cells is an osmotic process that is dependent upon chloride. The long term growth rate of GH-cells in medium in which chloride was exchanged with isethionate was completely normal, but, by 48 h, isethionate substitution resulted in a 70% decrease in the concentration of internal and secreted prolactin. Isethionate caused a much smaller reduction in growth hormone production (

Original languageEnglish (US)
Pages (from-to)15922-15927
Number of pages6
JournalJournal of Biological Chemistry
Volume263
Issue number31
StatePublished - 1988
Externally publishedYes

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Prolactin
Chlorides
Cultured Cells
Somatotrophs
Pituitary Neoplasms
Growth Hormone
Rats
Tumors
Substitution reactions
Growth

ASJC Scopus subject areas

  • Biochemistry

Cite this

Prolactin synthesis in cultured pituitary cells is chloride-dependent. / Day, Richard; Hinkle, P. M.

In: Journal of Biological Chemistry, Vol. 263, No. 31, 1988, p. 15922-15927.

Research output: Contribution to journalArticle

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