Proliferating thymolipoma: Ultrastructural, immunohistochemical, and flowcytometric study

M. T. Hull, K. A. Warfel, P. Kotylo, M. P. Goheen, John Brown

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A superior-anterior mediastinal tumor was excised from a 50-year-old man. The 207-g mass was encapsulated and multilobulated. It contained adipose tissue and abnormal thymic tissue. In some areas the thymic tissue was characterized by cords and nests of epithelial cells lying within either the adipose tissue or a myxoid matrix. Other areas were characterized by cortical thymic tissue with increased numbers of epithelial cells. Foci of normal medullary tissue were present. The prominent epithelial cells were immunoreactive for cytokeratin and nonimmunoreactive for vimentin, S-100, chromogranin, and parathyroid hormone. Flow cytometry showed that the lymphocyte populations were consistent with a late cortical thymic phenotype. The tumor was diploid. By electron microscopy, the prominent epithelial cells had desmosomes and a few tonofilaments. The cytoplasm contained additional organelles including mitochondria, polyribosomes, and occasional lysosomes. Nuclei were oval and had relatively smooth contours, prominent nucleoli, and moderate quantities of heterochromatin. Basal lamina was present around many nests and cords of cells. This is the first such study of a tumor with this histology.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalUltrastructural Pathology
Volume19
Issue number1
StatePublished - 1995

Fingerprint

Epithelial Cells
adipose tissues
Tissue
tumors
Adipose Tissue
Tumors
Chromogranins
lysosomes
Neoplasms
Desmosomes
organelles
phenotype
mitochondria
Polyribosomes
cytometry
histology
Intermediate Filaments
Heterochromatin
hormones
cytoplasm

Keywords

  • Flow cytometry
  • Immunohistochemistry
  • Thymic tumor/neoplasm
  • Thymolipoma
  • Thymus
  • Ultrastructure

ASJC Scopus subject areas

  • Structural Biology
  • Pathology and Forensic Medicine
  • Instrumentation

Cite this

Proliferating thymolipoma : Ultrastructural, immunohistochemical, and flowcytometric study. / Hull, M. T.; Warfel, K. A.; Kotylo, P.; Goheen, M. P.; Brown, John.

In: Ultrastructural Pathology, Vol. 19, No. 1, 1995, p. 75-81.

Research output: Contribution to journalArticle

Hull, M. T. ; Warfel, K. A. ; Kotylo, P. ; Goheen, M. P. ; Brown, John. / Proliferating thymolipoma : Ultrastructural, immunohistochemical, and flowcytometric study. In: Ultrastructural Pathology. 1995 ; Vol. 19, No. 1. pp. 75-81.
@article{bab1793edf18472b9f410d29461c766e,
title = "Proliferating thymolipoma: Ultrastructural, immunohistochemical, and flowcytometric study",
abstract = "A superior-anterior mediastinal tumor was excised from a 50-year-old man. The 207-g mass was encapsulated and multilobulated. It contained adipose tissue and abnormal thymic tissue. In some areas the thymic tissue was characterized by cords and nests of epithelial cells lying within either the adipose tissue or a myxoid matrix. Other areas were characterized by cortical thymic tissue with increased numbers of epithelial cells. Foci of normal medullary tissue were present. The prominent epithelial cells were immunoreactive for cytokeratin and nonimmunoreactive for vimentin, S-100, chromogranin, and parathyroid hormone. Flow cytometry showed that the lymphocyte populations were consistent with a late cortical thymic phenotype. The tumor was diploid. By electron microscopy, the prominent epithelial cells had desmosomes and a few tonofilaments. The cytoplasm contained additional organelles including mitochondria, polyribosomes, and occasional lysosomes. Nuclei were oval and had relatively smooth contours, prominent nucleoli, and moderate quantities of heterochromatin. Basal lamina was present around many nests and cords of cells. This is the first such study of a tumor with this histology.",
keywords = "Flow cytometry, Immunohistochemistry, Thymic tumor/neoplasm, Thymolipoma, Thymus, Ultrastructure",
author = "Hull, {M. T.} and Warfel, {K. A.} and P. Kotylo and Goheen, {M. P.} and John Brown",
year = "1995",
language = "English",
volume = "19",
pages = "75--81",
journal = "Ultrastructural Pathology",
issn = "0191-3123",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Proliferating thymolipoma

T2 - Ultrastructural, immunohistochemical, and flowcytometric study

AU - Hull, M. T.

AU - Warfel, K. A.

AU - Kotylo, P.

AU - Goheen, M. P.

AU - Brown, John

PY - 1995

Y1 - 1995

N2 - A superior-anterior mediastinal tumor was excised from a 50-year-old man. The 207-g mass was encapsulated and multilobulated. It contained adipose tissue and abnormal thymic tissue. In some areas the thymic tissue was characterized by cords and nests of epithelial cells lying within either the adipose tissue or a myxoid matrix. Other areas were characterized by cortical thymic tissue with increased numbers of epithelial cells. Foci of normal medullary tissue were present. The prominent epithelial cells were immunoreactive for cytokeratin and nonimmunoreactive for vimentin, S-100, chromogranin, and parathyroid hormone. Flow cytometry showed that the lymphocyte populations were consistent with a late cortical thymic phenotype. The tumor was diploid. By electron microscopy, the prominent epithelial cells had desmosomes and a few tonofilaments. The cytoplasm contained additional organelles including mitochondria, polyribosomes, and occasional lysosomes. Nuclei were oval and had relatively smooth contours, prominent nucleoli, and moderate quantities of heterochromatin. Basal lamina was present around many nests and cords of cells. This is the first such study of a tumor with this histology.

AB - A superior-anterior mediastinal tumor was excised from a 50-year-old man. The 207-g mass was encapsulated and multilobulated. It contained adipose tissue and abnormal thymic tissue. In some areas the thymic tissue was characterized by cords and nests of epithelial cells lying within either the adipose tissue or a myxoid matrix. Other areas were characterized by cortical thymic tissue with increased numbers of epithelial cells. Foci of normal medullary tissue were present. The prominent epithelial cells were immunoreactive for cytokeratin and nonimmunoreactive for vimentin, S-100, chromogranin, and parathyroid hormone. Flow cytometry showed that the lymphocyte populations were consistent with a late cortical thymic phenotype. The tumor was diploid. By electron microscopy, the prominent epithelial cells had desmosomes and a few tonofilaments. The cytoplasm contained additional organelles including mitochondria, polyribosomes, and occasional lysosomes. Nuclei were oval and had relatively smooth contours, prominent nucleoli, and moderate quantities of heterochromatin. Basal lamina was present around many nests and cords of cells. This is the first such study of a tumor with this histology.

KW - Flow cytometry

KW - Immunohistochemistry

KW - Thymic tumor/neoplasm

KW - Thymolipoma

KW - Thymus

KW - Ultrastructure

UR - http://www.scopus.com/inward/record.url?scp=0028902111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028902111&partnerID=8YFLogxK

M3 - Article

C2 - 7770964

AN - SCOPUS:0028902111

VL - 19

SP - 75

EP - 81

JO - Ultrastructural Pathology

JF - Ultrastructural Pathology

SN - 0191-3123

IS - 1

ER -