Prolongation of QT interval in isolated feline hearts by antipsychotic drugs

Milou Daniel Drici, Wen X. Wang, Xioa Ke Liu, Raymond L. Woosley, David A. Flockhart

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Some antipsychotic drugs have been found to prolong the QT interval on electrocardiographic (ECG) recordings, a phenomenon which, when severe, may facilitate the occurrence of complex ventricular arrhythmias such as torsade de pointes. However, the effects of these drugs on the cardiac repolarization process have not been evaluated extensively. This study was designed to examine the potency of five antipsychotic drugs in lengthening the QT interval of the perfused feline heart: haloperidol, risperidone, sertindole, clozapine, and olanzapine. The hearts were infused with increasing concentrations of drugs (0.1-20 μmol/L) for 40-minute intervals at each concentration. ECG recordings were made, with signals amplified and data recorded on a strip chart recorder. Four representative beats from each set of three signal recordings were chosen for QT interval measurement. Our data indicated that all tested drugs prolonged the QT interval in a concentration- dependent manner (p

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalJournal of Clinical Psychopharmacology
Volume18
Issue number6
DOIs
StatePublished - Dec 1998
Externally publishedYes

Fingerprint

Felidae
Antipsychotic Agents
olanzapine
Pharmaceutical Preparations
Torsades de Pointes
Risperidone
Clozapine
Haloperidol
Cardiac Arrhythmias

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Prolongation of QT interval in isolated feline hearts by antipsychotic drugs. / Drici, Milou Daniel; Wang, Wen X.; Liu, Xioa Ke; Woosley, Raymond L.; Flockhart, David A.

In: Journal of Clinical Psychopharmacology, Vol. 18, No. 6, 12.1998, p. 477-481.

Research output: Contribution to journalArticle

Drici, Milou Daniel ; Wang, Wen X. ; Liu, Xioa Ke ; Woosley, Raymond L. ; Flockhart, David A. / Prolongation of QT interval in isolated feline hearts by antipsychotic drugs. In: Journal of Clinical Psychopharmacology. 1998 ; Vol. 18, No. 6. pp. 477-481.
@article{1759f04651c84aa3aa2228bae9641b37,
title = "Prolongation of QT interval in isolated feline hearts by antipsychotic drugs",
abstract = "Some antipsychotic drugs have been found to prolong the QT interval on electrocardiographic (ECG) recordings, a phenomenon which, when severe, may facilitate the occurrence of complex ventricular arrhythmias such as torsade de pointes. However, the effects of these drugs on the cardiac repolarization process have not been evaluated extensively. This study was designed to examine the potency of five antipsychotic drugs in lengthening the QT interval of the perfused feline heart: haloperidol, risperidone, sertindole, clozapine, and olanzapine. The hearts were infused with increasing concentrations of drugs (0.1-20 μmol/L) for 40-minute intervals at each concentration. ECG recordings were made, with signals amplified and data recorded on a strip chart recorder. Four representative beats from each set of three signal recordings were chosen for QT interval measurement. Our data indicated that all tested drugs prolonged the QT interval in a concentration- dependent manner (p",
author = "Drici, {Milou Daniel} and Wang, {Wen X.} and Liu, {Xioa Ke} and Woosley, {Raymond L.} and Flockhart, {David A.}",
year = "1998",
month = "12",
doi = "10.1097/00004714-199812000-00011",
language = "English (US)",
volume = "18",
pages = "477--481",
journal = "Journal of Clinical Psychopharmacology",
issn = "0271-0749",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Prolongation of QT interval in isolated feline hearts by antipsychotic drugs

AU - Drici, Milou Daniel

AU - Wang, Wen X.

AU - Liu, Xioa Ke

AU - Woosley, Raymond L.

AU - Flockhart, David A.

PY - 1998/12

Y1 - 1998/12

N2 - Some antipsychotic drugs have been found to prolong the QT interval on electrocardiographic (ECG) recordings, a phenomenon which, when severe, may facilitate the occurrence of complex ventricular arrhythmias such as torsade de pointes. However, the effects of these drugs on the cardiac repolarization process have not been evaluated extensively. This study was designed to examine the potency of five antipsychotic drugs in lengthening the QT interval of the perfused feline heart: haloperidol, risperidone, sertindole, clozapine, and olanzapine. The hearts were infused with increasing concentrations of drugs (0.1-20 μmol/L) for 40-minute intervals at each concentration. ECG recordings were made, with signals amplified and data recorded on a strip chart recorder. Four representative beats from each set of three signal recordings were chosen for QT interval measurement. Our data indicated that all tested drugs prolonged the QT interval in a concentration- dependent manner (p

AB - Some antipsychotic drugs have been found to prolong the QT interval on electrocardiographic (ECG) recordings, a phenomenon which, when severe, may facilitate the occurrence of complex ventricular arrhythmias such as torsade de pointes. However, the effects of these drugs on the cardiac repolarization process have not been evaluated extensively. This study was designed to examine the potency of five antipsychotic drugs in lengthening the QT interval of the perfused feline heart: haloperidol, risperidone, sertindole, clozapine, and olanzapine. The hearts were infused with increasing concentrations of drugs (0.1-20 μmol/L) for 40-minute intervals at each concentration. ECG recordings were made, with signals amplified and data recorded on a strip chart recorder. Four representative beats from each set of three signal recordings were chosen for QT interval measurement. Our data indicated that all tested drugs prolonged the QT interval in a concentration- dependent manner (p

UR - http://www.scopus.com/inward/record.url?scp=0031730222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031730222&partnerID=8YFLogxK

U2 - 10.1097/00004714-199812000-00011

DO - 10.1097/00004714-199812000-00011

M3 - Article

VL - 18

SP - 477

EP - 481

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

SN - 0271-0749

IS - 6

ER -