Promise of endothelial progenitor cell for treatment of diabetic retinopathy

Ashay D. Bhatwadekar, Lynn C. Shaw, Maria B. Grant

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Progressive obliteration of the retinal microvessels is a characteristic of diabetic retinopathy. The resultant retinal ischemia leads to sight-threatening neovascularization and macular edema. Bone marrow-derived endothelial progenitor cells play a critical role in vascular maintenance and repair and forms the basis of cellular therapy for revascularization of ischemic myocardium and ischemic limbs. Emerging studies show potential of these cells in revascularization of ischemic retina and this review summarizes this possibility. We also report current pharmacological options to correct diabetes-associated defects in endothelial progenitor cells for their therapeutic transfer.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalExpert Review of Endocrinology and Metabolism
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2010

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Keywords

  • Diabetic retinopathy
  • Endothelial nitric oxide synthase
  • Endothelial progenitor cell

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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