Proposed endophenotypes of dysthymia: Evolutionary, clinical and pharmacogenomic considerations

Alexander Niculescu, H. S. Akiskal

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Dysthymia is highly prevalent - though underdiagnosed - occurring in at least 3% of the population. We conceptualize it as the clinical extension of adaptive traits that have developed during evolution to cope with stress and failure. A classification of dysthymias into anxious and anergic subtypes - and their putative association to bipolarity - is proposed. We further posit neurochemical and neurophysiological substrates for the two subtypes. A better recognition and understanding of dysthymic subtypes and their respective place in the affective spectrum will increase the proportion of people that may benefit from targeted treatments. It would also expand the pool of subjects that may be enrolled in genetic and pharmacogenomic research studies.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalMolecular Psychiatry
Volume6
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Endophenotypes
Genetic Research
Pharmacogenetics
Population
Pharmacogenomic Testing

Keywords

  • Dopamine
  • Dysthymia
  • Endophenotypes
  • Evolution
  • Gender
  • Genes
  • Neurasthenia
  • Pharmacogenomics
  • Serotonin

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Proposed endophenotypes of dysthymia : Evolutionary, clinical and pharmacogenomic considerations. / Niculescu, Alexander; Akiskal, H. S.

In: Molecular Psychiatry, Vol. 6, No. 4, 2001, p. 363-366.

Research output: Contribution to journalArticle

@article{8f89d6017038499da2fda1f0a9fd6529,
title = "Proposed endophenotypes of dysthymia: Evolutionary, clinical and pharmacogenomic considerations",
abstract = "Dysthymia is highly prevalent - though underdiagnosed - occurring in at least 3{\%} of the population. We conceptualize it as the clinical extension of adaptive traits that have developed during evolution to cope with stress and failure. A classification of dysthymias into anxious and anergic subtypes - and their putative association to bipolarity - is proposed. We further posit neurochemical and neurophysiological substrates for the two subtypes. A better recognition and understanding of dysthymic subtypes and their respective place in the affective spectrum will increase the proportion of people that may benefit from targeted treatments. It would also expand the pool of subjects that may be enrolled in genetic and pharmacogenomic research studies.",
keywords = "Dopamine, Dysthymia, Endophenotypes, Evolution, Gender, Genes, Neurasthenia, Pharmacogenomics, Serotonin",
author = "Alexander Niculescu and Akiskal, {H. S.}",
year = "2001",
doi = "10.1038/sj.mp.4000906",
language = "English (US)",
volume = "6",
pages = "363--366",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Proposed endophenotypes of dysthymia

T2 - Evolutionary, clinical and pharmacogenomic considerations

AU - Niculescu, Alexander

AU - Akiskal, H. S.

PY - 2001

Y1 - 2001

N2 - Dysthymia is highly prevalent - though underdiagnosed - occurring in at least 3% of the population. We conceptualize it as the clinical extension of adaptive traits that have developed during evolution to cope with stress and failure. A classification of dysthymias into anxious and anergic subtypes - and their putative association to bipolarity - is proposed. We further posit neurochemical and neurophysiological substrates for the two subtypes. A better recognition and understanding of dysthymic subtypes and their respective place in the affective spectrum will increase the proportion of people that may benefit from targeted treatments. It would also expand the pool of subjects that may be enrolled in genetic and pharmacogenomic research studies.

AB - Dysthymia is highly prevalent - though underdiagnosed - occurring in at least 3% of the population. We conceptualize it as the clinical extension of adaptive traits that have developed during evolution to cope with stress and failure. A classification of dysthymias into anxious and anergic subtypes - and their putative association to bipolarity - is proposed. We further posit neurochemical and neurophysiological substrates for the two subtypes. A better recognition and understanding of dysthymic subtypes and their respective place in the affective spectrum will increase the proportion of people that may benefit from targeted treatments. It would also expand the pool of subjects that may be enrolled in genetic and pharmacogenomic research studies.

KW - Dopamine

KW - Dysthymia

KW - Endophenotypes

KW - Evolution

KW - Gender

KW - Genes

KW - Neurasthenia

KW - Pharmacogenomics

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0034974908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034974908&partnerID=8YFLogxK

U2 - 10.1038/sj.mp.4000906

DO - 10.1038/sj.mp.4000906

M3 - Article

C2 - 11443518

AN - SCOPUS:0034974908

VL - 6

SP - 363

EP - 366

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 4

ER -