Proposed knobs-into-holes packing for several membrane proteins.

A. Dunker, T. C. Jones

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with hydrophobic exteriors and with hydrogen bonds between the side chains of one alpha-helix and the side chains of its knobs-into-holes packed neighbors.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalMembrane Biochemistry
Volume2
Issue number1
StatePublished - 1978
Externally publishedYes

Fingerprint

Knobs
Membrane Proteins
Proteins
Membrane Potentials
Hydrogen
Hydrogen bonds
alpha-Helical Protein Conformation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Proposed knobs-into-holes packing for several membrane proteins. / Dunker, A.; Jones, T. C.

In: Membrane Biochemistry, Vol. 2, No. 1, 1978, p. 1-16.

Research output: Contribution to journalArticle

@article{c5e7094632ef476aac6c13572bbb5fad,
title = "Proposed knobs-into-holes packing for several membrane proteins.",
abstract = "We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with hydrophobic exteriors and with hydrogen bonds between the side chains of one alpha-helix and the side chains of its knobs-into-holes packed neighbors.",
author = "A. Dunker and Jones, {T. C.}",
year = "1978",
language = "English (US)",
volume = "2",
pages = "1--16",
journal = "Molecular Membrane Biology",
issn = "0968-7688",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Proposed knobs-into-holes packing for several membrane proteins.

AU - Dunker, A.

AU - Jones, T. C.

PY - 1978

Y1 - 1978

N2 - We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with hydrophobic exteriors and with hydrogen bonds between the side chains of one alpha-helix and the side chains of its knobs-into-holes packed neighbors.

AB - We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with hydrophobic exteriors and with hydrogen bonds between the side chains of one alpha-helix and the side chains of its knobs-into-holes packed neighbors.

UR - http://www.scopus.com/inward/record.url?scp=0018200999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018200999&partnerID=8YFLogxK

M3 - Article

C2 - 45776

AN - SCOPUS:0018200999

VL - 2

SP - 1

EP - 16

JO - Molecular Membrane Biology

JF - Molecular Membrane Biology

SN - 0968-7688

IS - 1

ER -