Proposed knobs-into-holes packing for several membrane proteins

A. Keith Dunker, Theodore C. Jones

Research output: Contribution to journalArticle

18 Scopus citations


We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are αhelical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of αhelices with hydrophobic exteriors and with hydrogen bonds between the side chains of one αhelix and the side chains of its knobs-into-holes packed neighbors.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalMolecular Membrane Biology
Issue number1
StatePublished - Jan 1 1978
Externally publishedYes


  • Hydrogen-bonded chains
  • Membrane proteins
  • Mitchell's hypothesis
  • αhelices

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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