Prospective comparison of fine-needle aspiration cytology (FNAC) and histopathology in the diagnosis and subclassification of primary lymphomas

Ola Landgren, Anna Porwit-MacDonald, Edneia Tani, Magdalena Czader, Gunnar Grimfors, Lambert Skoog, Åke Ost, Christina Wedelin, Ulla Axdorph, Erik Svedmyr, Magnus Björkholm

Research output: Contribution to journalArticle

Abstract

Background. The accuracy of a malignant lymphoma diagnosis by FNAC remains controversial. The evaluation of the reliability of FNAC in comparison to histopathology in prospective studies is very limited. Patients/methods. One-hundred and seventy-seven patients (pts) >15 years of age with lymphadenopathy and accessible lymph nodes were included. Tissue samples from the same localization were consecutively studied by both FNAC and histopathology. Seventy-two (41%) pts were excluded due to non-matching site or timing (>2 months interval) of biopsy. Among remaining 106 pts there were 50 females and 56 males (median age 62; r 23-85). Immunostainings were performed on both FNAC and histopathological specimens. The primary histopathology diagnosis was reassessed in all histopathological specimens. The updated KIEL and REAL classifications were used. Results. FNAC and reassessed histopathology diagnoses were concordant in 87 (82%) pts. In 19 (18%) pts the diagnoses were discordant: 9 pts differed with regard to degree of malignancy (low vs. high-grade), 5 lymphoma vs. reactive changes, and 5 regarding Hodgkins disease (HD) vs. non-Hodgkin lymphoma (NHL). This difficulty with indistinction of HD and NHL concerned mainly cases of HD vs. large cell anaplastic lymphoma. Conclusion. We could confirm the usefulness of FNAC in the primary assessment of pts with lymphadenopathy. FNAC has the following main advantages: It is quick, inexpensive, and has limited complications. However, for classification and complementary analyses (e.g. molecular studies, etc) surgical biopsy/histopathology is required.

Original languageEnglish (US)
JournalBlood
Volume96
Issue number11 PART II
StatePublished - 2000
Externally publishedYes

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Cytology
Fine Needle Biopsy
Needles
Cell Biology
Lymphoma
Hodgkin Disease
Non-Hodgkin's Lymphoma
Biopsy
Anaplastic Large-Cell Lymphoma
Tissue
Lymph Nodes
Prospective Studies

ASJC Scopus subject areas

  • Hematology

Cite this

Landgren, O., Porwit-MacDonald, A., Tani, E., Czader, M., Grimfors, G., Skoog, L., ... Björkholm, M. (2000). Prospective comparison of fine-needle aspiration cytology (FNAC) and histopathology in the diagnosis and subclassification of primary lymphomas. Blood, 96(11 PART II).

Prospective comparison of fine-needle aspiration cytology (FNAC) and histopathology in the diagnosis and subclassification of primary lymphomas. / Landgren, Ola; Porwit-MacDonald, Anna; Tani, Edneia; Czader, Magdalena; Grimfors, Gunnar; Skoog, Lambert; Ost, Åke; Wedelin, Christina; Axdorph, Ulla; Svedmyr, Erik; Björkholm, Magnus.

In: Blood, Vol. 96, No. 11 PART II, 2000.

Research output: Contribution to journalArticle

Landgren, O, Porwit-MacDonald, A, Tani, E, Czader, M, Grimfors, G, Skoog, L, Ost, Å, Wedelin, C, Axdorph, U, Svedmyr, E & Björkholm, M 2000, 'Prospective comparison of fine-needle aspiration cytology (FNAC) and histopathology in the diagnosis and subclassification of primary lymphomas', Blood, vol. 96, no. 11 PART II.
Landgren, Ola ; Porwit-MacDonald, Anna ; Tani, Edneia ; Czader, Magdalena ; Grimfors, Gunnar ; Skoog, Lambert ; Ost, Åke ; Wedelin, Christina ; Axdorph, Ulla ; Svedmyr, Erik ; Björkholm, Magnus. / Prospective comparison of fine-needle aspiration cytology (FNAC) and histopathology in the diagnosis and subclassification of primary lymphomas. In: Blood. 2000 ; Vol. 96, No. 11 PART II.
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T1 - Prospective comparison of fine-needle aspiration cytology (FNAC) and histopathology in the diagnosis and subclassification of primary lymphomas

AU - Landgren, Ola

AU - Porwit-MacDonald, Anna

AU - Tani, Edneia

AU - Czader, Magdalena

AU - Grimfors, Gunnar

AU - Skoog, Lambert

AU - Ost, Åke

AU - Wedelin, Christina

AU - Axdorph, Ulla

AU - Svedmyr, Erik

AU - Björkholm, Magnus

PY - 2000

Y1 - 2000

N2 - Background. The accuracy of a malignant lymphoma diagnosis by FNAC remains controversial. The evaluation of the reliability of FNAC in comparison to histopathology in prospective studies is very limited. Patients/methods. One-hundred and seventy-seven patients (pts) >15 years of age with lymphadenopathy and accessible lymph nodes were included. Tissue samples from the same localization were consecutively studied by both FNAC and histopathology. Seventy-two (41%) pts were excluded due to non-matching site or timing (>2 months interval) of biopsy. Among remaining 106 pts there were 50 females and 56 males (median age 62; r 23-85). Immunostainings were performed on both FNAC and histopathological specimens. The primary histopathology diagnosis was reassessed in all histopathological specimens. The updated KIEL and REAL classifications were used. Results. FNAC and reassessed histopathology diagnoses were concordant in 87 (82%) pts. In 19 (18%) pts the diagnoses were discordant: 9 pts differed with regard to degree of malignancy (low vs. high-grade), 5 lymphoma vs. reactive changes, and 5 regarding Hodgkins disease (HD) vs. non-Hodgkin lymphoma (NHL). This difficulty with indistinction of HD and NHL concerned mainly cases of HD vs. large cell anaplastic lymphoma. Conclusion. We could confirm the usefulness of FNAC in the primary assessment of pts with lymphadenopathy. FNAC has the following main advantages: It is quick, inexpensive, and has limited complications. However, for classification and complementary analyses (e.g. molecular studies, etc) surgical biopsy/histopathology is required.

AB - Background. The accuracy of a malignant lymphoma diagnosis by FNAC remains controversial. The evaluation of the reliability of FNAC in comparison to histopathology in prospective studies is very limited. Patients/methods. One-hundred and seventy-seven patients (pts) >15 years of age with lymphadenopathy and accessible lymph nodes were included. Tissue samples from the same localization were consecutively studied by both FNAC and histopathology. Seventy-two (41%) pts were excluded due to non-matching site or timing (>2 months interval) of biopsy. Among remaining 106 pts there were 50 females and 56 males (median age 62; r 23-85). Immunostainings were performed on both FNAC and histopathological specimens. The primary histopathology diagnosis was reassessed in all histopathological specimens. The updated KIEL and REAL classifications were used. Results. FNAC and reassessed histopathology diagnoses were concordant in 87 (82%) pts. In 19 (18%) pts the diagnoses were discordant: 9 pts differed with regard to degree of malignancy (low vs. high-grade), 5 lymphoma vs. reactive changes, and 5 regarding Hodgkins disease (HD) vs. non-Hodgkin lymphoma (NHL). This difficulty with indistinction of HD and NHL concerned mainly cases of HD vs. large cell anaplastic lymphoma. Conclusion. We could confirm the usefulness of FNAC in the primary assessment of pts with lymphadenopathy. FNAC has the following main advantages: It is quick, inexpensive, and has limited complications. However, for classification and complementary analyses (e.g. molecular studies, etc) surgical biopsy/histopathology is required.

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