Prospective comparison of the immunological and stress response following laparoscopic and open surgery for localized renal cell carcinoma

Jaime Landman, Ephrem Olweny, Chandru P. Sundaram, Cathy Chen, Jamil Rehman, David I. Lee, Arieh Shalhav, Andrew Portis, Elspeth M. McDougall, Ralph V. Clayman

Research output: Contribution to journalArticle

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Abstract

Purpose: We prospectively compared the systemic immune and stress response of patients who underwent laparoscopic total nephrectomy (LRN) (14) and open nephrectomy (ON) (10) for renal cell carcinoma. The ON group comprised open radical (4), open total (2) and open partial (4) nephrectomy cases. Materials and Methods: Only patients with no history of cancer or autoimmune disease and American Society of Anesthesiologists score 2 or less who were not using immunosuppressive drugs were selected. Peripheral venous blood was collected preoperatively and intraoperatively, and 24 hours, 2 weeks, 4 weeks and 3 months postoperatively. Blood was analyzed for stress markers (adrenalin, noradrenalin and cortisol), inflammatory response markers (C-reactive protein, white blood count and leukocyte count), lymphocytic response markers (CD3, CD4 and CD8), cytokines interleukin-2 and 4, interferon-α and tumor necrosis factor-α), HLA-DR expression and the proliferative response to mitogen stimulation using concanavalin A, phytohemagglutinin 10, and pokeweed mitogen. Results: Mean tumor size ± SD for ON and LRN was 5.6 ± 2.4 and 4. 5 ± 1.6 cm, respectively (p = 0.21). The trends with time for all measured postoperative parameters were similar in the 2 groups. Inflammatory and stress response markers were statistically similar for in the groups at all time points. A significant difference between the groups was noted for the percentage of CD4+ and CD8+ lymphocytes. However, this difference was present preoperatively and there was no significant absolute change in these 2 parameters. The cytokine response and HLA-DR expression were similar in the 2 groups at all time points. Likewise, the lymphocytic stimulation index for concanavalin A, phytohemagglutinin and pokeweed mitogen were statistically similar for LRN and ON at all time points. Conclusions: The immunological and stress response after LRN and ON for renal cell carcinoma is similar. The few differences observed in measured parameters likely reflect preoperative differences in baseline and/or the contributory effect of anesthesia.

Original languageEnglish (US)
Pages (from-to)1456-1460
Number of pages5
JournalJournal of Urology
Volume171
Issue number4
DOIs
StatePublished - Apr 2004

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Nephrectomy
Renal Cell Carcinoma
Laparoscopy
Pokeweed Mitogens
Phytohemagglutinins
HLA-DR Antigens
Concanavalin A
Cytokines
Immunosuppressive Agents
Leukocyte Count
Mitogens
Interleukin-4
C-Reactive Protein
Interferons
Epinephrine
Autoimmune Diseases
Interleukin-2
Hydrocortisone
Neoplasms
Norepinephrine

Keywords

  • Carcinoma, renal cell
  • Kidney
  • Laparoscopy
  • Mitogens
  • Nephrectomy

ASJC Scopus subject areas

  • Urology

Cite this

Prospective comparison of the immunological and stress response following laparoscopic and open surgery for localized renal cell carcinoma. / Landman, Jaime; Olweny, Ephrem; Sundaram, Chandru P.; Chen, Cathy; Rehman, Jamil; Lee, David I.; Shalhav, Arieh; Portis, Andrew; McDougall, Elspeth M.; Clayman, Ralph V.

In: Journal of Urology, Vol. 171, No. 4, 04.2004, p. 1456-1460.

Research output: Contribution to journalArticle

Landman, J, Olweny, E, Sundaram, CP, Chen, C, Rehman, J, Lee, DI, Shalhav, A, Portis, A, McDougall, EM & Clayman, RV 2004, 'Prospective comparison of the immunological and stress response following laparoscopic and open surgery for localized renal cell carcinoma', Journal of Urology, vol. 171, no. 4, pp. 1456-1460. https://doi.org/10.1097/01.ju.0000118649.56016.1c
Landman, Jaime ; Olweny, Ephrem ; Sundaram, Chandru P. ; Chen, Cathy ; Rehman, Jamil ; Lee, David I. ; Shalhav, Arieh ; Portis, Andrew ; McDougall, Elspeth M. ; Clayman, Ralph V. / Prospective comparison of the immunological and stress response following laparoscopic and open surgery for localized renal cell carcinoma. In: Journal of Urology. 2004 ; Vol. 171, No. 4. pp. 1456-1460.
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abstract = "Purpose: We prospectively compared the systemic immune and stress response of patients who underwent laparoscopic total nephrectomy (LRN) (14) and open nephrectomy (ON) (10) for renal cell carcinoma. The ON group comprised open radical (4), open total (2) and open partial (4) nephrectomy cases. Materials and Methods: Only patients with no history of cancer or autoimmune disease and American Society of Anesthesiologists score 2 or less who were not using immunosuppressive drugs were selected. Peripheral venous blood was collected preoperatively and intraoperatively, and 24 hours, 2 weeks, 4 weeks and 3 months postoperatively. Blood was analyzed for stress markers (adrenalin, noradrenalin and cortisol), inflammatory response markers (C-reactive protein, white blood count and leukocyte count), lymphocytic response markers (CD3, CD4 and CD8), cytokines interleukin-2 and 4, interferon-α and tumor necrosis factor-α), HLA-DR expression and the proliferative response to mitogen stimulation using concanavalin A, phytohemagglutinin 10, and pokeweed mitogen. Results: Mean tumor size ± SD for ON and LRN was 5.6 ± 2.4 and 4. 5 ± 1.6 cm, respectively (p = 0.21). The trends with time for all measured postoperative parameters were similar in the 2 groups. Inflammatory and stress response markers were statistically similar for in the groups at all time points. A significant difference between the groups was noted for the percentage of CD4+ and CD8+ lymphocytes. However, this difference was present preoperatively and there was no significant absolute change in these 2 parameters. The cytokine response and HLA-DR expression were similar in the 2 groups at all time points. Likewise, the lymphocytic stimulation index for concanavalin A, phytohemagglutinin and pokeweed mitogen were statistically similar for LRN and ON at all time points. Conclusions: The immunological and stress response after LRN and ON for renal cell carcinoma is similar. The few differences observed in measured parameters likely reflect preoperative differences in baseline and/or the contributory effect of anesthesia.",
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AU - Olweny, Ephrem

AU - Sundaram, Chandru P.

AU - Chen, Cathy

AU - Rehman, Jamil

AU - Lee, David I.

AU - Shalhav, Arieh

AU - Portis, Andrew

AU - McDougall, Elspeth M.

AU - Clayman, Ralph V.

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N2 - Purpose: We prospectively compared the systemic immune and stress response of patients who underwent laparoscopic total nephrectomy (LRN) (14) and open nephrectomy (ON) (10) for renal cell carcinoma. The ON group comprised open radical (4), open total (2) and open partial (4) nephrectomy cases. Materials and Methods: Only patients with no history of cancer or autoimmune disease and American Society of Anesthesiologists score 2 or less who were not using immunosuppressive drugs were selected. Peripheral venous blood was collected preoperatively and intraoperatively, and 24 hours, 2 weeks, 4 weeks and 3 months postoperatively. Blood was analyzed for stress markers (adrenalin, noradrenalin and cortisol), inflammatory response markers (C-reactive protein, white blood count and leukocyte count), lymphocytic response markers (CD3, CD4 and CD8), cytokines interleukin-2 and 4, interferon-α and tumor necrosis factor-α), HLA-DR expression and the proliferative response to mitogen stimulation using concanavalin A, phytohemagglutinin 10, and pokeweed mitogen. Results: Mean tumor size ± SD for ON and LRN was 5.6 ± 2.4 and 4. 5 ± 1.6 cm, respectively (p = 0.21). The trends with time for all measured postoperative parameters were similar in the 2 groups. Inflammatory and stress response markers were statistically similar for in the groups at all time points. A significant difference between the groups was noted for the percentage of CD4+ and CD8+ lymphocytes. However, this difference was present preoperatively and there was no significant absolute change in these 2 parameters. The cytokine response and HLA-DR expression were similar in the 2 groups at all time points. Likewise, the lymphocytic stimulation index for concanavalin A, phytohemagglutinin and pokeweed mitogen were statistically similar for LRN and ON at all time points. Conclusions: The immunological and stress response after LRN and ON for renal cell carcinoma is similar. The few differences observed in measured parameters likely reflect preoperative differences in baseline and/or the contributory effect of anesthesia.

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KW - Kidney

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KW - Mitogens

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