Prospective description of coughing, hemodynamic changes, and oxygen desaturation during endoscopic sedation

Abdul Hamid El Chafic, George Eckert, Douglas K. Rex

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Deep sedation is increasingly used for endoscopy. The impact of sedation level on hemodynamic status, oxygenation, and aspiration risk is incompletely described. Aims: To describe the incidence of intraprocedural cough, hemodynamic changes, oxygen desaturation, and their relationship to clinical factors and sedation level. Methods: Detailed prospective recordings of hemodynamic changes, oxygen desaturation, and cough during 757 nonemergent endoscopic procedures done under sedation using propofol, midazolam, and/or fentanyl. Results: Thirteen percent of patients had at least one cough and 3% had prolonged cough. Cough was more common in nonsmokers (P = 0.05), upper endoscopy (P < 0.0001), with propofol (P = 0.0008), longer procedures (P = 0.0001), and hiccups (P = 0.01). The association between supine positioning during colonoscopy and cough approached significance (P = 0.06). Oxygen desaturation was rare (4%) and associated only with deep sedation (P = 0.02). Mean systolic and diastolic blood pressure (BP) dropped by 7.3 and 5.6% respectively. Decreases in systolic BP were more common in whites (P = 0.03), males (P = 0.004), nonsmokers (P = 0.04), during colonoscopy (P < 0.0001), and in patients receiving midazolam and fentanyl (P = 0.01). Heart rate (HR) dropped >20% from baseline in 15% of patients and was more common during colonoscopy (P = 0.002). HR increased >20% in 20% of patients and was more common with coughing (P < 0.0001) and in younger patients (P = 0.0002). No patient required pharmacologic treatment of BP or HR. Conclusions: We have described procedural predictors of cough that may help clinicians reduce the risk of aspiration during endoscopy. Hemodynamic changes during endoscopy are common but largely clinically insignificant.

Original languageEnglish (US)
Pages (from-to)1899-1907
Number of pages9
JournalDigestive diseases and sciences
Volume57
Issue number7
DOIs
StatePublished - Jul 1 2012

Keywords

  • Cough
  • Deep sedation/adverse effects
  • Digestive system/adverse effects
  • Endoscopy
  • Hemodynamics
  • Oxygen saturation
  • Propofol/adverse effects

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

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