Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis

F. A. Nicolini, J. L. Mehta, W. W. Nichols, T. G P Saldeen, M. Grant

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Platelets play an important role in the formation of a coronary thrombus and reocclusion after thrombolysis. Therefore, we examined the thrombolytic potential of concomitant intravenous administration of potent platelet inhibitor iloprost, a prostacyclin analogue, with tissue-type plasminogen activator (t-PA; n=8) and t-PA alone (n=9) in dogs with an electrically induced occlusive coronary artery thrombus. t-PA (0.75 mg/kg) was given over 20 minutes, and iloprost (4 μg/kg) was given over 40 minutes. Reperfusion rate was 63% (five of eight dogs) in the t-PA plus iloprost group and 67% (six of nine dogs) in the t-PA alone group (p=NS). The time to thrombolysis (or reperfusion) in the t-PA plus iloprost group was almost twice as great as in the t-PA alone group (33.0±13.3 vs. 18.5±6.7 minutes, mean±SD, p

Original languageEnglish (US)
Pages (from-to)1115-1122
Number of pages8
JournalCirculation
Volume81
Issue number3
StatePublished - Mar 1990
Externally publishedYes

Fingerprint

Iloprost
Coronary Thrombosis
Tissue Plasminogen Activator
Epoprostenol
Canidae
Dogs
Reperfusion
Thrombosis
Platelet Aggregation Inhibitors
Intravenous Administration
Coronary Vessels
Blood Platelets

Keywords

  • Iloprost
  • Platelet aggregation
  • Prostacyclin
  • Thrombolysis
  • Tissue-type plasminogen activator

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Nicolini, F. A., Mehta, J. L., Nichols, W. W., Saldeen, T. G. P., & Grant, M. (1990). Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. Circulation, 81(3), 1115-1122.

Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. / Nicolini, F. A.; Mehta, J. L.; Nichols, W. W.; Saldeen, T. G P; Grant, M.

In: Circulation, Vol. 81, No. 3, 03.1990, p. 1115-1122.

Research output: Contribution to journalArticle

Nicolini, FA, Mehta, JL, Nichols, WW, Saldeen, TGP & Grant, M 1990, 'Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis', Circulation, vol. 81, no. 3, pp. 1115-1122.
Nicolini, F. A. ; Mehta, J. L. ; Nichols, W. W. ; Saldeen, T. G P ; Grant, M. / Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. In: Circulation. 1990 ; Vol. 81, No. 3. pp. 1115-1122.
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